procarbazine


Also found in: Dictionary, Thesaurus, Wikipedia.

procarbazine

 [pro-kahr´bah-zēn]
an antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone in the regimen called MOPP for treatment of advanced Hodgkin's disease; it also has activity against non-Hodgkin's lymphomas and brain tumors.

procarbazine

(prō-kär′bə-zēn)
n.
A potent antineoplastic drug, C12H19N3O, used in its hydrochloride form in combination with other drugs to treat advanced Hodgkin lymphoma.

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.
 
Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.

procarbazine

Matulane® Oncology An alkylating therapeutic used as part of a multi-drug treatment for Hodgkin's disease Adverse effects BM suppression, N&V, neuropathy, confusion, swelling. See Hodgkins disease.

procarbazine

An anticancer drug used especially in the treatment of LYMPHOMAS. The drug is on the WHO official list. A brand name is Natulan.
References in periodicals archive ?
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial.
Procarbazine containing regimes result in prolonged azoospermia in the vast majority of patients.
Treatment for Hodgkin's lymphoma with MVPP (mechlorethamine, vinblastine, procarbazine and prednisolone), MOPP (mechlorethamine, vincristine, procarbazine and prednisolone) or ChIVPP (chlorambucil, vinblastine, procarbazine and prednisolone) resulted in permanent ovarian failure in 19 - 63% of cases.
Los farmacos mas conocidos que en altas dosis y casi siempre en combinacion con radioterapia craneal pueden producir dano a cualquier parte del sistema nervioso central son el BCNU o carmustine, cisplatin, cytarabine, 5-fluorouacil, ifosfamide, L-aspariginase, methotrexate, procarbazine, corticosteroides, y algunos modificadores de las respuestas biologicas como el interferon y el interleukin-2.
The researchers compared various chemotherapy regimens and IFRT doses and found that outcomes were similar when 30 Gy of IFRT was combined with either four cycles of ABVD (doxorubicine, bleomycin, vinblastine, and dacarbazine) or four cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone).
Effects of prenatal procarbazine administration on intrauterine development in rats.
The nodes were irradiated and she also received a course of procarbazine hydrochloride.
Plants have a long history of use in the treatment of cancer providing some of the currently used effective anticancer agents such as vinblastine, vincristine, mechlorethamine, prednisone, procarbazine, etoposide, teniposide, paclitaxel, bleomycin, cisplatin and taxanes (DeVita et al.
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.
He underwent mantle field radiation therapy and four cycles of MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) chemotherapy.
Treatment protocol: Most patients were treated with chemotherapy alone, alternating 4 cycles of COPP (cyclophosphamide, vincristine, procarbazine and prednisolone) with 4 cycles of ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine).
The drug that started it all, Mustargen, became a key element in the revolutionary MOPP (Mustargen, Oncovin, procarbazine, and prednisone) combination chemotherapy regimen pioneered by Dr.