procarbazine


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procarbazine

 [pro-kahr´bah-zēn]
an antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone in the regimen called MOPP for treatment of advanced Hodgkin's disease; it also has activity against non-Hodgkin's lymphomas and brain tumors.

procarbazine

/pro·car·ba·zine/ (pro-kahr´bah-zēn) an alkylating agent used as the hydrochloride salt as an antineoplastic, primarily in the treatment of Hodgkin's disease.

procarbazine

(prō-kär′bə-zēn)
n.
A potent antineoplastic drug, C12H19N3O, used in its hydrochloride form in combination with other drugs to treat advanced Hodgkin lymphoma.

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.
 
Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.

procarbazine

Matulane® Oncology An alkylating therapeutic used as part of a multi-drug treatment for Hodgkin's disease Adverse effects BM suppression, N&V, neuropathy, confusion, swelling. See Hodgkins disease.

procarbazine

An anticancer drug used especially in the treatment of LYMPHOMAS. The drug is on the WHO official list. A brand name is Natulan.

procarbazine

an antineoplastic agent that acts by inhibiting the synthesis of DNA, RNA and protein.
References in periodicals archive ?
To conclude the effect of cyclophosphamide and procarbazine containing chemotherapy is significant compared to the patients who received combinations without procarbazine.
Certain agents have been identified as particularly gonadotoxic to the testes, including the alkalating agents procarbazine, cisplatinum and vinblastine.
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.
Weihs noted that procarbazine inhibits dopamine beta-hydroxylase, while vincri- stine and vinblastine decrease conversion of dopamine to norepinephrine.
Weihs noted that procarbazine inhibits dopamine beta-hydroxylase, while vincristine and vinblastine decrease conversion of dopamine to norepinephrine.
In 1999 Temodar was granted accelerated approval for the treatment of adult patients with anaplastic astrocytoma (another form of brain cancer) in relapse after chemotherapy with nitrosourea and procarbazine.
Procarbazine Pronunciation: Pro-KAR-ba-zeen Brand names: Some commonly used brand names are Matulane[R] and Natulan[R].
6) The name "POCC" is derived from procarbazine, Oncovin, CCNU, and cyclophosphamide.
Chemotherapeutic regimens currently recommended for Hodgkin lymphoma are: ABVD- doxorubicin (Adriamycin), bleomycin, vinblastine, dacarbazine; Stanford V mechlorethamine, vincristine, prednisone, doxorubicin, bleomycin, vinblastine, etoposide; and COPP- cyclophosphamide, Oncovin, procarbazine, prednisone.
A randomized phase 2 trial of temozolomide versus procarbazine in 225 patients with GBM at first relapse demonstrated that treatment with temozolomide improved median progression-free survival (12.