The principal clinical and analytical characteristics of patients with CBZ-DILE are shown in Table 1 and are compared with idiopathic SLE, "classic" DILE (due to hydralazine and
procainamide), and anti-TNF-a DILE in Table 2.
The approach to the management of apical HCM is similar to most patients with HCM--medical therapy for symptomatic patients, which includes medications like verapamil and beta-blockers and antiarrhythmic agents such as amiodarone and
procainamide for treatment of atrial fibrillation and ventricular arrhythmias.
Nexus Pharmaceuticals disclosed on Thursday the availability of
Procainamide HCL Injection, USP in a multi dose vial containing 1,000 mg per 2 mL (500 mg/mL) or as a multi dose vial containing 1,000 mg per 10 ml (100 mg/ml) in the US with immediate effect.
QT prolongation refers to the prolonged QT interval in electrocardiography (ECG) which can even lead to life-threatening events such as ventricular arrhythmias, torsades de pointes, etc., several drugs can cause QT prolongation which includes sotalol, quinidine, arsenic, disopyramide,
procainamide, amiodarone, haloperidol, etc., Arsenic trioxide (ATO) is used as an effective treatment option in promyelocytic leukemia (PML).
Stable patients can be treated with intravenous amiodarone or
procainamide. Adenosine, diltiazem and verapamil are contraindicated in VT and should not be administered before the mechanism of WCT is certain [1, 2].
Antiarrhythmic medications like atropine, atenolol, fentoine,
procainamide and lidocaine could be used to control cardiac alterations (JOUBERT, 1989; PLUMB, 1999).
Our group has described how liposomes with nonbilayer phospholipid arrangements (NPA), induced by either chlorpromazine or
procainamide (known for triggering a lupus-like disorder in humans) or by the manganese cation, cause the development of an autoimmune disease resembling human lupus in syngeneic BALB/c and nonsyngeneic NIH mice, along with production of specific anti-NPA IgM and IgG antibodies [4].
Of the dozens of agents known to cause DIL,
procainamide and hydralazine remain the most common, with an incidence of 20% for
procainamide and 5-8% for hydralazine [1, 2].
Class Representative medications Class Ia antiarrhythmics Quinidine,
Procainamide Class Ib antiarrhythmics Lidocaine, Phenytoin Class Ic antiarrhythmics Propafenone, Flecainide Class III antiarrhythmics Amiodarone, Sotalol Tricyclic antidepressants Amitriptyline, Doxepin Antiepileptic medications Carbamazepine, Lamotrigine, Zonisamide, Lacosamide Selective serotonin Citalopram, Venlafaxine, reuptake inhibitors Fluoxetine Antihistamines Diphenhydramine Miscellaneous Cocaine, local anesthetics, Thioridazine, Propranolol, Amantadine, Chloroquine, Hydroxychloro quine, Cyclobenzaprine
* IV
procainamide or ibutilide are the agents of choice for AF with pre-excitation.
The most common causes of myasthenic crisis are: stress, surgery, infection, high body temperature and the use of certain drugs (aminoglycosides, quinolones, macrolides, beta blockers, calcium channel blockers, magnesium salts, iodine contrast, phenytoin,
procainamide).
[11.] Marill KA, deSouza IS, Nishijima DK, et al Amiodarone or
procainamide for the termination of sustained stable ventricular tachycardia: An historical multicenter comparison.
