J Seon-Min, J Song-Hae, J Moon-Kyoo, K Yeon-Hee, N Kyung-Tak, J Tae-Sook, et al., Comparison of antioxidant effects of naringin and probucol
in cholesterol-fed rabbits, Clin.
Evaluation of probucol
as suppressor of Ceftizoxime induced lipid peroxidation.
(8) have observed a greater than 40% reduction in LDL cholesterol and no drug-related adverse responses and cardiovascular events in four Chinese children following a triple combination of atorvastatin, probucol
, and ezetimibe during at least a 6-year follow-up period.
was initially designed as lipid-lowering drug but was never established in the clinic since it also exhibits HDL-lowering effects.
Efflux values are given as a percentage of total cell cholesterol and the contribution of pathways in the original studies was estimated using inhibitors of ABCA1 and SR-BI (probucol
and BLT-1), if other is not mentioned.
The polymer-free stent platform consists of a premounted, thin strut (50/60 [micro]m) cobaltchromium stent whose abluminal surface only is sandblasted to permit a microporous surface for the polymer-free matrix consisting of sirolimus and probucol
. Sirolimus with a concentration of 1.2 [micro]g/[mm.sup.2] is available on the abluminal stent surface only.
YAC128 and WT mice treated with either vehicle or probucol
were submitted to the open field test followed by the tail suspension test (TST) at 2, 4, and 6 months of age.
Chen et al., "G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol
," Journal ofControlled Release, vol.
Gong et al., "Effect of dietary fish oil, vitamin E, and probucol
on renal injury in the rat," Journal of Nutritional Biochemistry, vol.
Treatment with oxidized LDL (Ox-LDL) reduces the numbers of circulating MNCs and EPCs, and this effect is attenuated by probucol
, an ROS scavenger.
The pathophysiology is not clear, but an in vivo study shows that animals treated with 5-fluorouracil are characterized by vascular endothelial damage, that can be prevented by probucol
, a powerful antioxidant .
Zhao et al., "Probucol
inhibits neural cell apoptosis via inhibition of mTOR signaling pathway after spinal cord injury," Neuroscience, vol.