proband


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Related to proband: propositus, consultand

pro·band

(prō'band),
In human genetics, the patient or member of the family that brings a family under study.
Synonym(s): index case
[L. probo, to test, prove]

proband

/pro·band/ (pro´band) an affected person ascertained independently of relatives in a genetic study.

proband

(prō′bănd′, prō-bănd′)

proband

proband

Epidemiology A Pt who triggers study of other members of the family to identify the possible genetic factors involved in a given disease, condition, or characteristic. Cf Index case.

pro·band

(prō'band)
human genetics The patient or member of the family that brings a family under study.
[L. probo, to test, prove]

proband

The presenting patient of a group with an identical or similar disorder, especially the member of a family first found to have an inheritable disorder. Also known as propositus.

proband

an individual considered as the starting point for the study of a family for the inheritance of a particular condition.

proband

propositus.
References in periodicals archive ?
A priest could improve the chance that his proband would sink by directing him to exhale before entering the water.
These options should be considered for the proband and additional family members separately.
The positive kappa indicates some degree of agreement about the diagnosis of depression between diagnoses based on information provided by the proband versus diagnoses based on information provided by other informants.
The proband was 12 years old at the time that the accompanying radiographs were taken, and the platyspondyly had already resolved.
To overcome this problem, it is usually suggested to use linkage analysis and define the likelihood of transmission of mutant allele to the proband with a high accuracy.
Data were collected from 175 case-parent triads (96 complete case-triads: proband, father and mother; and 79 incomplete case-parents: proband, father or mother).
Other features such as acro-osteolysis and pes planus were absent in proband but present in the elder sibling.
Further investigation characterized the same mutation for mother and brother of the proband, whilst mother was also a carrier of an alpha thalassemia gene mutation (-a3.