An experimental study reported that
proarrhythmic effects are suggested on the ion channels of the sarcoplasmic reticulum and of the membrane and that the increase in oxidative stress probably contributes to the higher arrhythmic incidence mediated by the RAAS [111].
And I think maybe arrhythmia monitoring in the initial stages of putting patients on digoxin will be key to see if there are any additional
proarrhythmic effects."
The assessment of HRV before and after treatment with proton pump inhibitors, not only in the absence of this treatment, could bring new information, because therapy with proton pump inhibitors may have
proarrhythmic or antiarrhythmic effects (20,21).
The case for hypoglycaemia as a
proarrhythmic event: basic and clinical evidence.
Patients with left atrial diameters >4.5 cm are less likely to remain in sinus rhythm, and patients with left ventricular hypertrophy are at increased risk for
proarrhythmic adverse effects.
A decreased Cx43-p/Cx43-np ratio might induce a
proarrhythmic state under pathological conditions.
As a consequence of mechanical compression, PE leads to structural or hemodynamic consequences which may be
proarrhythmic [2, 3].
Developing a strategy for the nonclinical assessment of
proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization.
Inhomogeneous and asymmetric repolarization, reflected in ECG T-wave abnormalities, is associated with a greatly increased risk of arrhythmia, that is, a
proarrhythmic state.
On the other hand, some of the most active agents against this group of organisms belong to the macrolide or fluoroquinolone classes, which are both types of antimicrobial drugs with potential
proarrhythmic effects (39,40).
Ferrari, "Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the
proarrhythmic effect," British Journal of Pharmacology, vol.
This study evaluates a drug's risk of QT prolongation and its
proarrhythmic potential, and is a standard component of all clinical development programmes for new molecular entities.
