An experimental study reported that proarrhythmic
effects are suggested on the ion channels of the sarcoplasmic reticulum and of the membrane and that the increase in oxidative stress probably contributes to the higher arrhythmic incidence mediated by the RAAS .
And I think maybe arrhythmia monitoring in the initial stages of putting patients on digoxin will be key to see if there are any additional proarrhythmic
The assessment of HRV before and after treatment with proton pump inhibitors, not only in the absence of this treatment, could bring new information, because therapy with proton pump inhibitors may have proarrhythmic
or antiarrhythmic effects (20,21).
The case for hypoglycaemia as a proarrhythmic
event: basic and clinical evidence.
Patients with left atrial diameters >4.5 cm are less likely to remain in sinus rhythm, and patients with left ventricular hypertrophy are at increased risk for proarrhythmic
A decreased Cx43-p/Cx43-np ratio might induce a proarrhythmic
state under pathological conditions.
As a consequence of mechanical compression, PE leads to structural or hemodynamic consequences which may be proarrhythmic
Developing a strategy for the nonclinical assessment of proarrhythmic
risk of pharmaceuticals due to prolonged ventricular repolarization.
Inhomogeneous and asymmetric repolarization, reflected in ECG T-wave abnormalities, is associated with a greatly increased risk of arrhythmia, that is, a proarrhythmic
On the other hand, some of the most active agents against this group of organisms belong to the macrolide or fluoroquinolone classes, which are both types of antimicrobial drugs with potential proarrhythmic
Ferrari, "Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic
effect," British Journal of Pharmacology, vol.
This study evaluates a drug's risk of QT prolongation and its proarrhythmic
potential, and is a standard component of all clinical development programmes for new molecular entities.