prior therapy

prior therapy

Any therapy given to a patient for a particular condition before starting a new regimen for managing the same condition. Prior therapy is of particular interest when enrolling a patient in a clinical study or trial.
References in periodicals archive ?
The submissions are based on Phase 2 data from a Phase 1/2 clinical trial of lorlatinib, evaluating patients treated in distinct cohorts based on prior therapy.
DARZALEX is indicated in Europe for use in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of adult patients with multiple myeloma who have received at least one prior therapy and as monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a PI and an immunomodulatory agent and who have demonstrated disease progression on the last therapy.
The trial is enrolling patients with activating EGFR mutations across three settings that include Arm A that is designed to determine the daily dose of bemcentinib that can be safely administered in combination with erlotinib in patients who have received prior erlotinib therapy, Arm B follows a Simon-like two-stage design evaluating the ability of bemcentinib to restore sensitivity to EGFR targeted therapy when given in combination with erlotinib in patients who have progressed on prior therapy with an approved EGFR inhibitor and that are negative for the T790M mutation, and Arm C designed to evaluate the ability of bemcentinib to prevent acquired resistance to EGFR targeted therapy when given in combination with erlotinib first line.
Novartis announced today that the European Commission (EC) approved Tasigna (nilotinib) for the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase (Ph+ CML-CP) and pediatric patients with Ph+ CML-CP with resistance or intolerance to prior therapy including imatinib.
It will be made available to adult patients after prior therapy.
The marketing authorisation allows the product to be used in combination with chlorambucil or bendamustine to treat patients who have not received prior therapy.
Food and Drug Administration (FDA) approval for IMBRUVICA (ibrutinib) capsules as a single, oral agent for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.
Today, the distinct tolerability profile of BOSULIF offers physicians an important therapeutic choice for their patients with Ph+ CML, as has already been shown in patients who are resistant or intolerant to prior therapy.
Clavis will continue to concentrate on elacytarabine and its Phase III study dubbed CLAVELA in patients with acute myeloid leukaemia (AML) who have failed prior therapy.
is seeking approval of omacetaxine for the treatment of adults with chronic myeloid leukemia (CML) after failure on prior therapy with imatinib (Gleevec) and with the Bcr-Abl T3151 mutation.
Sprycel is currently approved for treating adults with resistance or intolerance to prior therapy for chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia.
Another key finding suggests that, despite popular assumptions that O-T-Cs are always lower-cost alternatives to prescriptions, most of those who switched to O-T-C Zyrtec paid more out of pocket than they did for their prior therapy.