So the pluripotent stem cell population is not pure, due to the appearance of primed cells with lower levels of Myc.
When the research team blocked cell competition, differentiated cells accumulated in the pluripotent stem cell population, which had become less pure when primed cells could not be eliminated through cell competition.
Additionally, issues on how vaccination (both with pathogen products or primed cells
, such as dendritic cell) can alter the host-pathogen dynamic will be explored.
Four hours later, primed cells
were treated with rottlerin (3, 10, and 30 [micro]M) or vehicle for 12 h.
These primed cells
are then re-administered to the patient to stimulate a specific immune response to the cancer antigen(s) contained in the vaccine.
These results demonstrate the enhanced sensitivity of primed cells
to both indoor and outdoor fine particles, which has been shown previously for CAP samples (23,29).