primary testicular failure

primary testicular failure

A congenital, developmental or genetic defect in sperm production by the seminiferous tubules, which may be complete or partial—in which latter case, patchy areas of sperm production will be found in the testis.

Lab
Marked elevation of FSH levels.
References in periodicals archive ?
Hypogonadism may be hypergonadotropic (primary testicular failure with loss of feedback inhibition leading to increased LH and FSH) or hypogonadotropic (hypothalamic-pituitary disease causing absolute or relative gonadotropin deficiency).
In males, hypogonadism is commonly seen and may have primary testicular failure. The earliest and most common presenting feature is postaxial polydactyly.
Serum FSH elevations are indicative of disturbances in spermatogenesis such as primary testicular failure (hypergonadotropic hypogonadism), although normal FSH levels do not dismiss spermatogenic failure.
Patients with azoospermia, total necrospermia, recurrent varicocele, and pituitary hormonal abnormalities (such as high LH, FSH denoting primary testicular failure) were excluded from the study.
Patients with Klinefelter syndrome tend to have a pattern of primary testicular failure, such as low to low-normal testosterone and elevated luteinizing hormone (LH), follicular stimulating hormone (FSH), and serum estradiol.
Serum hormone levels testosterone, LH and FSH were advised to determine whether the patient had gonadotropin deficiency (low testosterone and low or inappropriately normal LH and FSH), primary testicular failure (low testosterone, elevated LH and FSH), selective spermatogenic failure (normal testosterone and LH, elevated FSH), or androgen resistance (high testosterone, elevated LH).
Testosterone deficiency can result from defects in testicular production of androgens (primary testicular failure), at the hypothalamic-pituitary level (secondary failure), or from combined mechanisms.
Gonadotropin levels can help delineate whether hypogonadism is caused by primary testicular failure (hypergonadotropic hypogonadism) or by pituitary disease (hypogonadotropic hypogonadism).
* Men with primary testicular failure who require hormone replacement.