primary testicular failure

primary testicular failure

A congenital, developmental or genetic defect in sperm production by the seminiferous tubules, which may be complete or partial—in which latter case, patchy areas of sperm production will be found in the testis.

Lab
Marked elevation of FSH levels.
References in periodicals archive ?
22) With the exclusion of cases of high LH or FSH denoting primary testicular failure from our study, we found that the duration of infertility and preoperative LH and FSH levels did not affect the impact of the varicocelectomy on postoperative semen analysis.
In the US, GONAL-f(R) Multi-Dose, available as the GONAL-f(R) 1050 IU vial or GONAL-f(R) 450 IU vial is indicated for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due to primary testicular failure as well as for ovulation induction and the development of multiple follicles in the ovulatory female patient participating in an Assisted Reproductive Technology (ART).
Primary testicular failure is associated with diminished testosterone levels and elevated gonadotropin levels, which result in a hypergonadotropic hypogonadal pattern.
FSH, the active ingredient in Gonal-F(R), induces ovulation in women and production of sperm in men, provided that the cause of their infertility is not due to primary testicular failure.
It was illuminating that in this clinical trial less than 5% of the 600 patients screened were characterized as having primary testicular failure as determined by elevated LH, the pituitary hormone responsible for driving the testicular production of testosterone.
Cystic fibrosis gene mutations and infertile men with primary testicular failure.