primary immune response


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im·mune re·sponse

1. any response of the immune system to an antigen including antibody production and/or cell-mediated immunity;
2. the response of the immune system to an antigen (immunogen) that leads to the condition of induced sensitivity; the immune response to the initial antigenic exposure (primary immune response) is detectable, as a rule, only after a lag period of from several days to 2 weeks; the immune response to a subsequent stimulus (secondary immune response) by the same antigen is more rapid than in the case of the primary immune response.

im·mune re·sponse

(i-myūn' rĕ-spons')
1. Any response of the immune system to an antigen including antibody production or cell-mediated immunity.
2. The response of the immune system to an antigen (immunogen) that leads to the condition of induced sensitivity; the immune response to the initial antigenic exposure (primary immune response) is detectable, as a rule, only after a lag period of from several days to 2 weeks; the immune response to a subsequent stimulus (secondary immune response) by the same antigen is more rapid than in the case of the primary immune response.

primary immune response

The weak initial reaction caused by the first encounter of a ‘naive’ lymphocyte with a particular antigen. Antibodies are nor detectable for several days then rise to a (low) peak concentration and then fall again. If now there is a second challenge with the same antigen, there is a more rapid and much higher rise in the level of antibodies. This is the secondary immune response.
References in periodicals archive ?
When an animal receives the first injection of vaccine, the primary immune response takes place.
CD74 is an important piece of cellular machinery inside dendritic cells - which regulate mammalian primary immune responses.
Since the ability to mount primary immune responses relies on the availability of naive T cells, the circulating naive T-cell reservoir was evaluated throughout the human life span.

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