Valproate can be the antiepileptic drug of choice as it is one of the most effective agents for controlling seizures in patients with primary generalized epilepsy
, said Dr.
Psychopathology in pediatric complex partial and primary generalized epilepsy
Meador, "There is a subgroup of women with primary generalized epilepsy
who may only respond to valproate.
Patients with refractory primary generalized epilepsy
are going to end up on multiple medications--and one of them is often Depakote [valproate]," noted Dr.
The newer agents are indicated for add-on therapy of partial seizures, as well as for primary generalized epilepsy
among patients who have weight gain or other difficulties with an older drug.
Juvenile myoclonic epilepsy: Characteristics of a primary generalized epilepsy.
On the genetics of the primary generalized epilepsy with sporadic myoclonias of impulsive petit mal type.
Neuron density in the molecular layer of the frontal cortex in primary generalized epilepsy
In a study with 94 women with epilepsy and 23 control women, those with primary generalized epilepsy
(PGE) who were also treated with valproate had a 55% prevalence of ovulatory failure, said Dr.
In a study with 94 women with epilepsy and 23 control women, those who had primary generalized epilepsy and were treated with valproate had a 55% prevalence of ovulatory failure, said Dr.
Among the women with seizure disorder, 59 had localization-related epilepsy and 35 had primary generalized epilepsy.
Similarly an MRI "should be seriously considered in any child with a significant cognitive or motor impairment of unknown etiology unexplained abnormalities on neurologic examination, a seizure of partial (focal) onset with or without secondary generalization, [or] an EEG that does not represent a benign partial epilepsy of childhood or primary generalized epilepsy
, or in children under 1 year of age," the practice parameter states.