In our study, the serum level of PEA, an enzyme related to OS and inflammation, was evaluated as a biomarker of the pathogenesis of epilepsy among patients with primary generalized epilepsy
There were no statistically significant differences in serum PEA levels between patients with epilepsy and members of the healthy control group.
Therefore, cranial MRI should be performed in patients with epilepsy who have normal brain tomography except for patients with primary generalized epilepsy
Generalized tonic-clonic seizures can occur in primary generalized epilepsy
(now termed as Genetic Generalized Epilepsy) or in partial epilepsy where the seizures are secondarily generalized.
Valproate can be the antiepileptic drug of choice as it is one of the most effective agents for controlling seizures in patients with primary generalized epilepsy
, said Dr.
In 1957 Janz and Christian were the first to observe that patients with juvenile myoclonic epilepsy (JME), a type of primary generalized epilepsy
, were more likely to fall asleep later and get up later than their peers and suffer from prolonged morning drowsiness and are most active in the afternoon and evening time .
Psychopathology in pediatric complex partial and primary generalized epilepsy
. Dev Med Child Neurol 1998; 40:805-811.
Meador, "There is a subgroup of women with primary generalized epilepsy
who may only respond to valproate.
"Patients with refractory primary generalized epilepsy
are going to end up on multiple medications--and one of them is often Depakote [valproate]," noted Dr.
The newer agents are indicated for add-on therapy of partial seizures, as well as for primary generalized epilepsy
among patients who have weight gain or other difficulties with an older drug.
Neuron density in the molecular layer of the frontal cortex in primary generalized epilepsy
. Epilepsia 1985; 26: 450-4.
In a study with 94 women with epilepsy and 23 control women, those with primary generalized epilepsy
(PGE) who were also treated with valproate had a 55% prevalence of ovulatory failure, said Dr.