primary cutaneous follicle centre lymphoma
primary cutaneous follicle centre lymphomaAn indolent, localised lymphoma of follicle centre cells—mostly centrocytes with some centroblasts—which comprises 12% of lymphomas, and is not typically associated with nodal disease.
Independent of histologic grade—based on number of centroblasts.
Most commonly in the head and neck; extracutaneous spread is rare. PCFCL in the legs and cases expressing FOX-P1 have a worse prognosis and require aggressive therapy similar to that used for diffuse large B-cell lymphoma (DLBCL).
5-year rate 90–95%; recurs in up to 40%.
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