primary amebic meningoencephalitis

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Related to primary amebic meningoencephalitis: Naegleria fowleri


inflammation of the brain and its meninges; called also encephalomeningitis.
primary amebic meningoencephalitis a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria, Acanthamoeba, and Hartmannella.

pri·mar·y a·me·bic me·nin·go·en·ceph·a·li·tis

an invasive, rapidly fatal cerebral infection by soil amebae, chiefly Naegleria fowleri, found in humans and other primates and experimentally in rodents; the disease is characterized by a high fever, neck rigidity, and symptoms associated with upper respiratory infection such as cough and nausea; although organisms have been cultured from various organs, the brain is the primary focus, especially the olfactory lobes and cerebral cortex, which are first attacked by amebae that enter from nasal mucosa through the cribriform plate; death usually occurs 2-3 days after onset of symptoms.

primary amebic meningoencephalitis

An intracranial infection by free-living amoebae–eg, Naegleria fowleri, N grubei, Acanthamoeba, Hartmannella, Entamoeba histolytica, etc Clinical Acute, purulent meningoencephalitis–typically by Naegleria spp–in young healthy persons swimming in stagnant, artificial fresh water lakes; inflammation and hemorrhage is most intense along the olfactory tract, inculpating the cribriform plate as the portal of entry via the nose Prognosis Poor; the few Pts who survive are treated with parenteral amphotericin B, miconazole, rifampicin, and have major sequelae; PAM may also be subacute with a granulomatous reaction, a finding more common in immunocompromised hosts
References in periodicals archive ?
Production of monoclonal antibodies to Naegleria fowleri, agent of primary amebic meningoencephalitis. Journal of Clinical Microbiology, 25(9), 1629-1634.
Primary amebic meningoencephalitis caused by Naeglaeria fowleri, Karachi, Pakistan.
Initially, several search engines were queried for references using the following key MESH words: free-living amebae, free-living amebic infections, primary amebic meningoencephalitis, PAM, Naegleria species, Naegleria fowleri, and climate change, specifically the impact of climate change on parasites and infectious diseases of aquatic environments.
fowleri, is known to infect humans by causing an acute, usually lethal, central nervous system (CNS) infection known as primary amebic meningoencephalitis (PAM).
(7, 8) Table 1 contrasts clinical, diagnostic laboratory, and neuroimaging features of primary amebic meningoencephalitis with the only two known causes of granulomatous amebic encephalitis, Acanthamoeba and Balamuthia mandrillaris.
A case of primary amebic meningoencephalitis in a Nigerian farmer.
Successful treatment of primary amebic meningoencephalitis. N Eng J Med 1982;306:346-8.
PCR has been used to identify ameba DNA in brain tissue and CSF of persons suspected of having balamuthiasis (2) and in brain tissue of a patient with primary amebic meningoencephalitis caused by N.
During September 1991, two children in North Carolina died from primary amebic meningoencephalitis (PAM), a rare and often fatal illness resulting from infection with Naegleria fowleri.
We report the first case of primary amebic meningoencephalitis in Italy, in a 9-year-old boy.
Primary amebic meningoencephalitis (PAM) is invariably an acute, often fulminant infection caused by Naegleria fowleri, a small, free-living ameba that occasionally infects humans and other mammals.
The stipulation that at least two persons be ill is waived for single cases of chemical poisoning, if laboratory studies indicate that water was contaminated by the chemical, and for single cases of laboratory-confirmed primary amebic meningoencephalitis. If prinmary and secondary cases are distinguished on the outbreak report form, only primary cases are included in the case counts on the line listings.

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