These include primary acquired melanosis (PAM), melanoma, conjunctival/corneal intra-epithelia neoplasia (CCIN) and SCC.
Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: Review of the evidence and recommendations for treatment.
Differential diagnosis includes other conjunctival melanocytic lesions such as primary acquired melanosis
(PAM), conjunctival melanoma or secondary pigmentation in conjunctival intraepithelial neoplasia (CIN III), and squamous cell carcinoma.
It is further subdivided into primary acquired melanosis (PAM) without atypia and PAM with atypia.
2) Primary acquired melanosis is most common in middle-aged or elderly white individuals.
28,29) Primary acquired melanosis with atypia has been associated with a 36% to 75% risk of progression to melanoma, whereas PAM without atypia is not believed to be a precursor lesion.
28) Primary acquired melanosis without atypia is not considered a premalignant lesion and does not require treatment.
About 75% will arise from cases of primary acquired melanosis
When is referral of Primary Acquired Melanosis
to ophthalmology NOT indicated?
Importantly, the authors discuss unique terminology of conjunctival melanocytic proliferations used by ophthalmic oncologists and provide a detailed update on the clinical and pathologic features of conjunctival nevi, primary acquired melanosis
, and melanoma.
Another ocular lesion, primary acquired melanosis, can encompass several different histologic patterns, both benign and malignant.
Primary acquired melanosis that involves the limbus is highly suggestive of malignant melanoma.