presynaptic

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presynaptic

 [pre″sĭ-nap´tik]
situated or occurring proximal to a synapse.

pre·syn·ap·tic

(prē'sin-ap'tik),
Pertaining to the area on the proximal side of a synaptic cleft.

presynaptic

/pre·syn·ap·tic/ (-sĭ-nap´tik) situated or occurring proximal to a synapse.

presynaptic

(prē′sĭ-năp′tĭk)
adj.
Situated in front of or occurring before a synapse: a presynaptic nerve fiber; a presynaptic stimulus.

presynaptic

[-sinap′tik]
Etymology: L, prae + synaptein, to join
1 situated near or before a synapse.
2 before a synapse is crossed.

pre·syn·ap·tic

(prē'si-nap'tik)
Pertaining to the area on the proximal side of a synaptic cleft.

presynaptic

proximal side of a synapse

presynaptic

situated or occurring proximal to a synapse.
References in periodicals archive ?
For example, GABAB receptors are present on GABAergic terminals synapsing on dopaminergic neuron of the VTA; activation of these receptors presynaptically attenuates the release of GABA in the VTA.
2013) Anandamide, cannabinoid type 1 receptor, and NMDA receptor activation mediate nonHebbian presynaptically expressed long-term depression at the first central synapse for visceral afferent fibers.
Botulinum toxin acts presynaptically at cholinergic nerve terminals by preventing acetylcholine exocytosis and release and causes muscle paresis which can last for two to three months (1,2).
According to the company, the intellectual property is a method of treating Tourette Syndrome using GABA aminotransferase inhibitor drugs, including CPP-109 and CPP-115, which significantly increase presynaptically stored GABA, and enhance GABA signalling in the striatal-thalamo-cortical tracts involved in habit formation and motor control.
To achieve this, trains of action potentials were stimulated presynaptically while simultaneously recording postsynaptic responses in an assay cell contacting B110 neurites (Fig.
5) Presynaptically, 5-HTlAare autoreceptors, ie, serotonin stimulation of these receptors results in inhibition of firing of 5-HT neurons, while postsynaptically they may be involved in downstream serotonergic effects such as sexual function.
We used PPF to test the hypothesis that TDE, galanthamine and ACh reduce synaptic responses by presynaptically depressing glutamatergic release.
Both receptors are primarily localized presynaptically and are thought to function as autoreceptors.
presynaptically, in the synaptic region of the postsynaptic cell, or in the membrane more distant from the synapse [i.
Tetrabenazine decreases the jerky, involuntary movements of chorea in Huntington's disease by reversibly inhibiting vesicular monoamine transporter 2, depleting monoamines presynaptically and depleting dopamine preferentially over norepinephrine and/or 5-hydroxytryptamine, according to its manufacturer, Prestwick Pharmaceuticals Inc.
Tetrabenazine is a centrally acting drug that reversibly inhibits vesicular monoamine transporter-2 (VMAT-2), depletes monoamines presynaptically, and depletes dopamine preferentially over norepinephrine and/or 5-hydroxytryptamine, according to Prestwick Pharmaceuticals.
The excess glutamate feeds back presynaptically and inhibits normal release of glutamate, leading to memory problems and impairment in the ability to think clearly," Dr.