2+] to the presynaptic membrane
and then neurotransmitters such as glutamate, acetylcholine, and GABA are released in the form of vesicles.
This process involves the fusion of the presynaptic vesicle, which contains acetylcholine with the presynaptic membrane
and is mediated by a set of SNARE (soluble N-ethylmaleimide-sensitive fusion attachment protein receptor) proteins (Smith & Chancellor, 2004).
Another explanation is the modulation of neuromuscular transmission, due to lowered number of vesicles fused with the presynaptic membrane
and quantal size of acetylcholin (ACh) per vesicle (Reid et al.
Choline is recycled by an active pump at the presynaptic membrane
for the formation of more acetylcholine.
cruzi, as well as ischemia and alterations in the presynaptic membrane
densities in the active zones, shows that the abnormal mice NMJ is associated with an activity dependent modulation of the neurotransmission, producing abnormal motor activity and paralysis of the rear limbs mice while still in the acute Chagas'disease.
A neuromuscular junction is comprised of three components--the presynaptic membrane
, the synaptic cleft, and the postsynaptic membrane.
5 nm/msec, which is not far from the right order of magnitude, bearing in mind the distances of the vesicles from the presynaptic membrane
(3) and the exocytosis process times.
1] Autoreceptors on the presynaptic membrane
, or even the presynaptic cell body, are often indirect and regulate transmitter release.
The vesicles formed a single layer along the presynaptic membrane
, which was surrounded by a granular, dense matrix.
2]-adrenergic receptors that exist on the presynaptic membrane
of both serotonergic (i.
When the endorphin system is activated, opiate receptor sites are filled with endorphins that block the release and slow the production of chemical messengers of pain (substance P) from the presynaptic membrane
In Torpedo these forms constitute 40% of total AChE; the hydrophobic (6S) form, localized in the presynaptic membrane
, accounts for the other 60% (Li and Bon, 1983).