mansoni infection (SMI) is due to egg-induced inflammation and fibrosis in liver
presinusoidal portal areas, leading to portal hypertension, esophageal varices formation and digestive bleeding.
However, in a subset of infected individuals, severe hepatic fibrosis occurs due to excessive deposition of extracellular matrices in portal spaces in response to trapped Schistosoma egg leading to
presinusoidal fibrosis and portal hypertension [1, 2].
Idiopathic noncirrhotic portal hypertension (INCPH) has many etiologies, but a common denominator is vascular resistance at various locations that include the intrahepatic sinusoidal and
presinusoidal as well as extrahepatic portal and hepatic veins [1].
The causes of noncirrhotic portal hypertension can be separated into prehepatic, intrahepatic (
presinusoidal, sinusoidal, and post sinusoidal), and post hepatic causes1.
Presinusoidal portal hypertension in non-alcoholic cirrhosis.
Schistosoma mansoni produces several hundred eggs per day, and proportion of these eggs is trapped in hepatic tissues and in
presinusoidal venules.
Massive variceal hemorrhage secondary to
presinusoidal portal hypertension due to arsenic poisoning.
Presinusoidal: Cuando las lesiones comprimen las ramificaciones portales antes de alcanzar las sinusoides hepaticas; tal es el tipo de hipertension portal de la esquistosomiasis, de la fibrosis hepatica congenita u ocasionalmente la sarcoidosis.
Resultados de la derivacion mesenterico-cava con injerto autologo de yugular en la hipertension portal
presinusoidal en el nino.
A bony defect was seen in the
presinusoidal region near the posterior fossa (figure 2).