Houston et al., "Diagnostic classification of arterial spin labeling and structural MRI in presenile
early stage dementia," Human Brain Mapping, vol.
Subjects were evaluated in terms of age at presentation, gender, distribution of diagnoses in the presenile
(65-74 years old) and senile (75 years and older) age groups, near and distance visual acuity, and low vision aids (LVAs) used for near and distance.
LBD is now defined as follows: "LBD is a chronic progressive neuropsychiatric disorder, which is clinically characterized by Parkinson symptoms of presenile
or senile, or sometimes younger onset, often followed by dementia at the later stages.
dementia," Journal of Neurology Neurosurgery and Psyehiatry, vol.
Van Broeckhoven, "Novel APP mutation V715A associated with presenile
Alzheimer's disease in a German family," Journal of Neurology, vol.
Two autopsy cases of presenile
onset with minimal involvement of the brainstem.
The primary endpoint was new diagnosis of presenile
and senile dementia.
According to the diagnostic criteria of the Chinese Classification of Mental Disorders, third edition (CCMD-3) (1)--a national classification and diagnostic system widely used by psychiatrists in China--AD dementia is divided into 3 subtypes: senile dementia, presenile
dementia, and mixed dementia.
The regulatory change comes after an Institute of Medicine (IOM) study found "sufficient evidence of an association" between moderate or severe TBI and Parkinsonism; dementias (which VA understands to include presenile
dementia of the Alzheimer type and post-traumatic dementia); depression (which also was associated with mild TBI); and diseases of hormone deficiency that may result from hypothalamo-pituitary changes.
Disability Classification Timeframe Unprovoked seizures moderate or severe N/A (diagnosed) Parkinson's moderate or severe N/A Dementia (1) moderate or severe within 15 years Depression mild within 12 months Depression moderate or severe within three years Diseases of hormone moderate or severe within 12 months deficiency (2) (1) Specific to presenile
dementia of the Alzheimer type and post-traumatic dementia (2) Specific to diseases that result from hypothalamo-pituitary changes
She was diagnosed in 1901 by Alois Alzheimer, who examined Ms Deter's brain when she died and he described the distinctive damage as an indicator of a form of presenile