preprotein

preprotein

 [pre-pro´tēn]
a protein precursor that contains a signal peptide sequence; it is a nonpolar sequence at the head of the growing polypeptide chain and is required for its transfer into the cistern of the endoplasmic reticulum; the signal sequence is then cleaved to form the protein or proprotein.

pre·pro·tein

(prē-prō'tēn),
A secretory protein with a signal peptide region attached.
References in periodicals archive ?
This investigation unearthed seven essential human nonhomologous metabolic proteins, of which three were membranous proteins including preprotein translocase subunit SecD (T1, gene reference 218562707), cbb3-type cytochrome c oxidase subunit I (T2, gene reference 218563091) and preprotein translocase subunit SecE (T3, gene reference 218562127).
2234 2104679 T T G SP70585_2289 Position Gene product Synonymous 384518 Hypothetical protein No 425383 Helicase, RecD/TraA family No 457503 Not applicable -- 568204 Not applicable -- 923459 Dihydroorotate dehydrogenase 1B No 936681 Competence protein No 1389846 Pyridoxal biosynthesis lyase PdxS No 1675901 Preprotein translocase subunit SecY No 2044455 # beta-N-Acetylglucosaminidase/ No beta-glucosidase (3- beta-N-acetyl-D- glucosaminidase/ beta-D-glucosidase) (Nag3) 2104679 alpha-L-Fucosidase No Position Amino acid change 384518 K [right arrow] * 425383 R [right arrow] H 457503 -- 568204 -- 923459 S [right arrow] A 936681 K [right arrow] N 1389846 E [right arrow] * 1675901 T [right arrow] I 2044455 # E [right arrow] A 2104679 S [right arrow] R # SNV is located in the genomic island.
Amyloid-[beta]-peptide induces mitochondrial dysfunction by inhibition of preprotein maturation," Cell Metabolism, vol.
Eleven SNPs were shared only by Papworth and Seattle cystic fibrosis outbreak strains (n = 9), including nonsynonymous mutations in the preprotein translocase secA1 and a putative lyase (Figure 2; online Technical Appendix).
Indeed, through screening of the human protein database, we found several secretory proteins that have similar T(or S)-X(n)-RXXR [down arrow] sequences, including endothelin 1 pre-prohormone (40TPSPPWRLRRSIR 2 C) and von Willebrand factor preprotein (768SHRSKR [down arrow] S).
The six additional Nematostella loci that exhibit significant similarity to the "fibronectin type II" domain are best matches to human notch 2 preprotein, relaxin, vitrin, neuronal pentaxin, neuropilin, and semaphorin.
In this preprotein world, RNA served the role of both DNA (informational) and proteins (catalytic).
02 hevein preprotein protein (latex coagulation) Hev b 6.
Epitopes in the hevein preprotein are recognized by latex-allergic individuals previously unidentified.
NM_014080) is 6376 nucleotides long, and the preprotein is composed of a putative 26-amino acid signal peptide followed by a 1522-amino acid polypeptide (31).
The "RNA World" hypothesis describes a preprotein world where RNA was able to both carry genetic information (later evolved into DNA) and act as biocatalysts (most of them replaced by proteins).