preprotein

preprotein

 [pre-pro´tēn]
a protein precursor that contains a signal peptide sequence; it is a nonpolar sequence at the head of the growing polypeptide chain and is required for its transfer into the cistern of the endoplasmic reticulum; the signal sequence is then cleaved to form the protein or proprotein.

pre·pro·tein

(prē-prō'tēn),
A secretory protein with a signal peptide region attached.
References in periodicals archive ?
The apelin gene encodes a secreted preprotein of 77 amino acids with a prodomain, a signal peptide, and a C-terminal peptide.
Briefly, in rodents, the BDNF gene consists of nine 5' untranslated exons, each linked to individual promoter regions, and a 3' coding exon (IX), which codes for the BDNF preprotein amino acid sequence [7].
After translocation to the endoplasmic reticulum, the preprotein is cleaved of and pro-apoA-I is secreted into blood and lymph.
Hill et al., "Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase," Nature, vol.
Primary antibodies used (a) mouse monoclonal anti-RyR1/RyR3 34C (1:20) (Developmental Studies Hybridoma Bank, University of Iowa, Iowa, USA) and (b) rabbit polyclonal antimitochondrial preprotein translocases of the outer membrane, TOM20 (1:50) (Santa Cruz Biotechnology, Inc., Dallas, TX, USA).
This investigation unearthed seven essential human nonhomologous metabolic proteins, of which three were membranous proteins including preprotein translocase subunit SecD (T1, gene reference 218562707), cbb3-type cytochrome c oxidase subunit I (T2, gene reference 218563091) and preprotein translocase subunit SecE (T3, gene reference 218562127).
The "RNA World" hypothesis describes a preprotein world where RNA was able to both carry genetic information (later evolved into DNA) and act as biocatalysts (most of them replaced by proteins).
Taskin et al., "Amyloid-[beta]-peptide induces mitochondrial dysfunction by inhibition of preprotein maturation," Cell Metabolism, vol.
In addition, peptides [J0I929_HELPX.sub.1-11] (MIIGGGVSGCA) derived from HP quinone oxidoreductase J0I929_HELPX protein (UniProtKB accession number J0I929) and [T2T4W3_HELPX.sub.99-105] (AGIVLTV) derived from HP preprotein translocase subunit T2T4W3_HELPX (UniProtKB accession number T2T4W3), respective homologs of [ZnT8.sub.178-186] and [ZnT8.sub.186-194], were synthesized by the same manufacturer at >90% purity.
Eleven SNPs were shared only by Papworth and Seattle cystic fibrosis outbreak strains (n = 9), including nonsynonymous mutations in the preprotein translocase secA1 and a putative lyase (Figure 2; online Technical Appendix).
Indeed, through screening of the human protein database, we found several secretory proteins that have similar T(or S)-X(n)-RXXR [down arrow] sequences, including endothelin 1 pre-prohormone (40TPSPPWRLRRSIR 2 C) and von Willebrand factor preprotein (768SHRSKR [down arrow] S).
The six additional Nematostella loci that exhibit significant similarity to the "fibronectin type II" domain are best matches to human notch 2 preprotein, relaxin, vitrin, neuronal pentaxin, neuropilin, and semaphorin.