SAP2 encodes 398-residue preproprotein
that is processed to a 342-residue mature enzyme, a typical aspartic proteinase having an optimum pH between 3 and 4 and inhibited by pepstatin A .
Gene Description Accession Fold name number change ADH4 Alcohol dehydrogenase 4 F7GMI7 0.45 GCK Glucokinase F6PLG6 0.50 MPO Myeloperoxidase F7BAA9 2.00 CELF6 CUGBP Elav-like family member 6 F7GCB0 2.00 ANXA3 Annexin (fragment) F6Z8Y2 2.00 CTSD Cathepsin D preproprotein
F7H7Y3 2.05 TNC Tenascin C F7ECK5 2.06 CA1 Carbonic anhydrase 1 F7CLQ5 2.09 COL6A3 Collagen alpha-3(VI) chain isoform 4 I2CWG4 2.17 KRT1 Keratin 1 F7B777 2.17 FGA Fibrinogen alpha chain F6UZ60 2.22 FGG Fibrinogen gamma F6UYY8 2.39 LDHA L-lactate dehydrogenase H9ES85 2.43 NNMT Nicotinamide N-methyltransferase F7ERX8 2.48 FABP4 Adipocyte-type fatty acid-binding F7GLY0 3.00 protein CRP C-reactive protein F7DHQ1 3.47 Table 3: The enriched terms (or function) of differential expression genes.
This nonsynonymous polymorphism results in the change in amino acid at position 190 in BMP-2 preproprotein
from arginine to serine (Styrkarsdottir et al., 2003).
(c) 287 Transformation upregulated 460789 51.0/5.1 nuclear protein 631 26S proteasome non-ATPase 157502193 42.9/5.5 regulatory subunit 13 isoform 1 720 60S acidic ribosomal protein P0 4506667 34.2/5.7 735 60S acidic ribosomal protein P0 4506667 34.2/5.7 749 60S acidic ribosomal protein P0 4506667 34.2/5.7 858 Cathepsin D preproprotein
4503143 44.5/6.1 899 NADH-Ubiquinone reductase 4758788 30.2/6.9 905 Enoyl-CoA hydratase 1922287 31.3/8.3 Spot MW (kDa)/pI Sequence MOWSE Peptides number Exp.
Human GNRH1, on chromosome 8, composed by four exons separated by three introns, encodes a 92 amino acids preproprotein
(pre-pro-GnRH), consisting of a signal sequence (23 amino acids) sequentially followed by two serine residues, the GnRH decapeptide, a GKR sequence, and a 56-amino acid peptide called GAP (GnRH-associated peptide) [58,59].
(5) PCSK9 is synthesized in the endoplasmic reticulum (ER) as a preproprotein
of 692 amino acid residues.
Largely produced in the liver and the intestine (6), PCSK9 is synthesized in the endoplasmic reticulum (ER) as a preproprotein
of692 amino acid residues (6).
BACE-1 is synthesized as a 501-amino acid-long preproprotein
[relative molecular mass ([M.sup.r]) 56 000] and processed to a 456-residue fully enzymatically active membrane-bound form.
The nucleotide sequence of the five coding exons of hKLK2 predicts the production of a 261-amino acid preproprotein
that includes a signal peptide of 17 amino acids and an activation peptide of 7 amino acids, similar to the structure of hPSA .
Thus, in general, signal peptides from preproproteins
have not previously been considered measurable immunoassay targets; however, some evidence suggests that signal peptide fragments may lend themselves to such a purpose (12, 13).