preproinsulin

preproinsulin

 [pre″pro-in´soo͡-lin]
the precursor of proinsulin, containing an additional polypeptide sequence at the N-terminal.

pre·pro·in·su·lin

(prē'prō-in'sū-lin),
The precursor protein to proinsulin. See: preprotein.
References in periodicals archive ?
In the islets of the high carbohydrate group, the mRNA expression of preproinsulin, somatostatin transcription facto r-1, upstream stimulatory factor-1, stress-activated protein kinase-2, phosphatidylinositol kinase, and glucose transporter-2 was increased.
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Heterozygous dominant negative INS mutations cause abnormal preproinsulin and proinsulin structures to be produced.
It is produced in an immature form called preproinsulin, which is proteolytically cleaved to obtain proinsulin and then insulin.
Rutter, "Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression," Biochemical Journal, vol.
It concludes that the presence of cDNA corresponding to preproinsulin and proinsulin was [beta]-glucuronidase positive for several lines.
Our observed attenuation of PI3K and IRS mRNA did not, however, affect insulin synthesis--PLHF animals were hyperinsulinemic, and preproinsulin mRNA concentrations were elevated.
As reported in Table 1 all the samples were amplified in a linear amplification range established using a serial cDNA dilution and varying the number of cycles (28 cycles for Actin, Preproinsulin and PDX-1; 40 cycles for Nrf2).
Son yillarda preproinsulin (INS) geninde, insulin yapi ve biyosentezini etkileyen mutasyonlar saptanmistir.
CnIs, particularly tacrolimus, decrease the insulin content of [beta] cells and preproinsulin mRNA production and dampen glucose activation of the insulin promoter (37), thereby giving rise to diabetes mellitus-like symptoms, such as insulin resistance, hyperglycemia, and islet cell antibody formation [reviewed in (38)].
Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.