preproinsulin

[pre″pro-in´soo͡-lin]

the precursor of proinsulin, containing an additional polypeptide sequence at the N-terminal.

pre·pro·in·su·lin

(prē'prō-in'sū-lin),

The precursor protein to proinsulin. See: preprotein.

Mentioned in ?

References in periodicals archive ?

In the islets of the high carbohydrate group, the mRNA expression of preproinsulin, somatostatin transcription facto r-1, upstream stimulatory factor-1, stress-activated protein kinase-2, phosphatidylinositol kinase, and glucose transporter-2 was increased.

The Japanese Wagyu beef industry: current situation and future prospects--A review

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes

Heterozygous dominant negative INS mutations cause abnormal preproinsulin and proinsulin structures to be produced.

Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity

It is produced in an immature form called preproinsulin, which is proteolytically cleaved to obtain proinsulin and then insulin.

Global Type 2 Diabetes Therapeutics Market 2015-2019 - New Report Available

Rutter, "Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression," Biochemical Journal, vol.

Augmented [beta]-cell function and mass in glucocorticoid-treated rodents are associated with increased islet Ir-[beta]/AKT/mTOR and decreased AMPK/ACC and AS160 signaling

It concludes that the presence of cDNA corresponding to preproinsulin and proinsulin was [beta]-glucuronidase positive for several lines.

Research panorama on the second green revolution in the world and Colombia/Panorama investigativo sobre la segunda revolucion verde en el mundo y en Colombia

Our observed attenuation of PI3K and IRS mRNA did not, however, affect insulin synthesis--PLHF animals were hyperinsulinemic, and preproinsulin mRNA concentrations were elevated.

Timing of maternal exposure to a high fat diet and development of obesity and hyperinsulinemia in male rat offspring: same metabolic phenotype, different developmental pathways?

As reported in Table 1 all the samples were amplified in a linear amplification range established using a serial cDNA dilution and varying the number of cycles (28 cycles for Actin, Preproinsulin and PDX-1; 40 cycles for Nrf2).

Glucagon-like peptide-1 triggers protective pathways in pancreatic beta-cells exposed to glycated serum

Son yillarda preproinsulin (INS) geninde, insulin yapi ve biyosentezini etkileyen mutasyonlar saptanmistir.

Neonatal diabetes mellitus/ Yenidoganda diyabetes mellitus

CnIs, particularly tacrolimus, decrease the insulin content of [beta] cells and preproinsulin mRNA production and dampen glucose activation of the insulin promoter (37), thereby giving rise to diabetes mellitus-like symptoms, such as insulin resistance, hyperglycemia, and islet cell antibody formation [reviewed in (38)].

Molecular diagnostics of calcineurin-related pathologies

(2000) verified the biosynthesis of preproinsulin in the epithelial cells of the colon, in the intestinal crypts and in some glandular cells in the rat stomach.

Quantification of argyrophillic, argentaffin and insulin immunoreactive cells in the small intestine in the opossum Didelphis aurita (Wied-Neuwied, 1826)/Quantificacao das celulas argirofilas, argentafins e imunorreativas a insulina nos diferentes segmentos do intestino delgado do gamba Didelphis aurita (Wied-Neuwied, 1826)

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.