The precursor of collagen that is synthesized on ribosomes; procollagen with a leader or signal sequence that directs the polypeptide chain into the vesicular space of the endoplasmic reticulum.
Farlex Partner Medical Dictionary © Farlex 2012
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This involves the formation of pro-alpha chains, preprocollagen, procollagen, and tropocollagen fibrils and finally in the extracellular space copper-dependent lysyl oxidases (LOX) enzymatically create the intramolecular and intermolecular cross-links that form the mature collagen fibrils.
(2) in ER [right arrow] preprocollagen, (3) ER Lumen [right arrow] signal peptides cleaved; proline and lysine hydroxylation, 2 pro-alpha1 and 1 pro-alpha2 chains [right arrow] Type I procollagen, triple helix formed [right arrow] (4) in Golgi packaged and secreted [right arrow] (5) outside cell propeptides cleaved [right arrow] tropocollagen fibrils formed, (6) lysyl oxidase creates intramolecular and intermolecular cross-links.
These peptide chains are known as preprocollagen and have a signal peptide and propeptides on each end.