osteoprogenitor cell

(redirected from preosteoblast)

os·te·o·gen·ic cell

one of the cells in the inner layer of the periosteum that develop into osteoblasts.

os·te·o·pro·gen·i·tor cell

(os'tē-ō-prō-jen'i-tŏr sel)
A mesenchymal cell that differentiates into an osteoblast.
Synonym(s): preosteoblast.

osteoprogenitor cell

Any of the mesenchyme precursor cells committed to the bone lineage and capable of producing osteoblasts and osteocytes. Osteoprogenitor cells are found in bone, bone marrow, and other connective tissue.
See also: cell
References in periodicals archive ?
HEPM cells demonstrated the ability to differentiate from a preosteoblast cell to an osteoblast over a 3-week time course [27].
Akao, "MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-inducedmouse preosteoblast differentiation by targeting distal-less homeobox 5," Journal of Biological Chemistry, vol.
Preosteoblast cell lines MC3T3-E1 was obtained from American Type Culture Collection (ATCC).
No significant staining was observed when MC3T3 were cultured in normal growth medium while a staining was observed when cells were cultured in OM, indicating the need of osteogenic inductors for differentiation of these preosteoblast cells.
MC3T3-E1(ATCC CRL-2953) cells, a clonal preosteoblast cell line derived from newborn mouse calvaria, were cultured in a-modified Eagle medium (Gibco), supplemented with 10% fetal bovine serum and 1% penicillin streptomycin and kept at 37[degrees]C in a saturated humid atmosphere containing 95% air and 5% C[O.sub.2].
Mandal and colleagues demonstrated that apart from its antimicrobial function NOX4 is responsible not only for osteoclast but also for preosteoblast differentiation via ROS accumulation reinforcing the idea of NOX4 as a key regulator in bone remodeling under physiological ROS amounts [47].
By further osteogenic differentiation, it shapes into the preosteoblast. At the final stage, the mature osteoblast came in line.
Studies in vitro indicated that neuropeptides, such as substance P and CGRP [11], could influence preosteoblast cells.
The in vitro biocompatibility was evaluated in terms of proliferation of preosteoblast cells.
In these two stages, PEMF regulated preosteoblast gene expression and most genes were downregulated including transcriptional regulators, metabolism, proteases, and regulators and also cell adhesion and binding proteins and cytoskeletal and structural proteins.
Here, we cultured preosteoblast cell line MC3T3-E1 in vitro, and observed cellular proliferation and apoptosis after risperidone administration.
Another study revealed that conditional deletion of Bmpr1a in differentiated osteoclasts negatively regulates osteoclast differentiation.[25] However, osteoblast-specific deletion of Bmpr1a resulted in increased bone volume with marked decreases in bone formation rate (BFR) in tibias at 8 weeks of age.[26] Thus, physiological Bmpr1a signaling in bone exerts a dual function in both restricting preosteoblast proliferation and promoting osteoblast activity.