Investigations were performed for premature pubarche
with the findings as follows;follicle stimulating hormone: 0.78 mlU/mL (0.26-3), luteinizing hormone: 0.2 mIU/mL (0.02-0.3) free testosterone: 1.4 pg/mL (0.4-0.9), total testosterone: 0.1 ng/dL (<2.5-10), dehydroepiandrosterone sulfate: 93 mcg/dL (13-83), 17-OH progesterone: 4.8 ng/mL (<0.9) cortisol: 12 mcg/dL (3-21), adrenocorticotropic hormone: 22 pg/mL (6-48) and bone age of 8 years.
Natural history of premature pubarche
: an auxological study.
Prevalence of nonclassic congenital adrenal hyperplasia in Turkish children presenting with premature pubarche
, hirsutism, or oligomenorrhoea.
Clinical features of 11-[beta]-hydroxylase deficiency in childhood might be premature pubarche
and accelerated bone age, all of which occurred in our patient.
Subject number 1, a girl, presented with premature pubarche
and accelerated growth velocity at the age of 4 years.
and Gharravi et al.21,22 Also, another study performed in the Netherlands demonstrated that there was no association between menarche and BMI.23 Other European studies have found that there is no significant increased BMI in girls with a history of premature pubarche
at ages 6-18 years (although increased central fat was noted).24
We recommend that pediatricians ascertain risk for PCOS in their patients, including maternal factors, family history, birth weight, metabolic factors, and history of premature pubarche
and/or early thelarche,'" Dr.
'We recommend that pediatricians as certain risk for PCOS in their patients, including maternal factors, family history, birth weight, metabolic factors, and history of premature pubarche
and/or early thelarche," Dr.
The differences were particularly striking in the subset of PA girls who also had premature pubarche
Androgens regulate several physiologic processes, such as normal prostate development and maintenance of male sexual function in adult life, and they are also involved in pathologic conditions, including prostate cancer, prepubertal gynecomastia, and premature pubarche
. Androgens enter the target cell and bind to androgen receptor (AR), a ligand-dependent transcription factor in the nuclear receptor superfamily comprising receptors for vitamin D3 and thyroid and steroid hormones (1, 2).
, hyperinsulinemia and hypothyroxinemia: novel manifestations of congenital portosystemic shunts (Abernethy malformation) in children.
In most of the studies it has been seen that girls with premature adrenarche (the onset of pubic hair before the age of 8 years is associated with elevated levels of adrenal androgens and no evidence of true puberty or adrenal dysfunction) may be at increased risk for development of polycystic ovarian syndrome (PCOS).22 Premature pubarche
is not studied in the present data.