Subject number 1, a girl, presented with premature pubarche and accelerated growth velocity at the age of 4 years.
Pro267Leu mutation was identified in a girl that was investigated for premature pubarche at 4 years of age.
Clinical features of 11-[beta]-hydroxylase deficiency in childhood might be premature pubarche
and accelerated bone age, all of which occurred in our patient.
23 Other European studies have found that there is no significant increased BMI in girls with a history of premature pubarche
at ages 6-18 years (although increased central fat was noted).
We recommend that pediatricians ascertain risk for PCOS in their patients, including maternal factors, family history, birth weight, metabolic factors, and history of premature pubarche
and/or early thelarche,'" Dr.
We recommend that pediatricians as certain risk for PCOS in their patients, including maternal factors, family history, birth weight, metabolic factors, and history of premature pubarche
and/or early thelarche," Dr.
The differences were particularly striking in the subset of PA girls who also had premature pubarche
Androgens regulate several physiologic processes, such as normal prostate development and maintenance of male sexual function in adult life, and they are also involved in pathologic conditions, including prostate cancer, prepubertal gynecomastia, and premature pubarche
22 Premature pubarche
is not studied in the present data.
These include a BMI above the 85th percentile for age and sex, polycystic ovarian syndrome, hypertension, dyslipidemia, a history of small size for gestational age at birth, premature pubarche
, allergic diathesis, and/or a family history of these conditions.
Girls diagnosed with premature pubarche
show an exaggerated ovarian androgen synthesis from the early stages of puberty: evidence for gonadotropin-releasing hormone agonist testing.