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Related to preleukemia: Myelodysplastic syndrome


a stage of bone marrow dysfunction preceding the development of acute myelogenous leukemia. adj., adj preleuke´mic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

myelodysplastic syndrome

a heterogeneous group of clonal hematopoietic stem cell disorders characterized by the presence of dysplastic changes in one or more of hematopoietic lineages. The common clinical picture may include anemia, infections, and bleeding problems. Occurs generally in elderly patients, or those with prior exposure to leukemogenic agents. Transformation rates to acute leukemia range from 10-80%. Cytogenetic abnormalities are associated with a poor prognosis.
Farlex Partner Medical Dictionary © Farlex 2012


Myelodysplastic syndrome, smoldering leukemia Any of a heterogeneous group of clonal expansions of stem cells, characterized by dysmyelopoiesis–a complex of structural and functional defects–eg, abnormal cell morphology, ineffective hematopoiesis, chromosome defects–eg, aneuploidy and pseudodiploidy Examples Acquired idiopathic sideroblastic and nonsideroblastic anemias, pancytopenia with hypercellular marrow, paroxysmal nocturnal hemoglobinuria, which may all progress to ANLL
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

my·e·lo·dys·plas·tic syn·drome

(mī'ĕ-lō-dis-plast'ik sin'drōm)
A primary, neoplastic, pluripotential stem cell disorder characterized by peripheral blood cytopenias and prominent maturation abnormalities in the bone marrow. The disease evolves progressively and may transform into leukemia. Classified by the French-American-British (FAB) system (q.v.) into five groups.
Synonym(s): chronic erythremic myelosis, preleukemia, smoldering leukemia.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Dysplasia, erythroplasia, leukoplasia, lymphomatoid granulomatosis and papulosis, preleukemia and xeroderma pigmetosum are all conditions which, if left untreated, may lead to cancer.
Human preleukemia : identification of a maturation defect in vitro.
Myelodysplastic syndrome is a disease in which the bone marrow does not function normally and is sometimes referred to as preleukemia or "smoldering leukemia".
Hexagonal crystals in the bone marrow of patients with myeloproliferative disease and preleukemia. Scand J Haematol.
Leukemia and preleukemia in Fanconi anemia patients: a review of the literature and report of the International Fanconi Anemia Registry.
After conducting genetic analyses of 13 patients with leukemia or preleukemia syndromes, she and her colleagues concluded that the gene for this regulatory protein lies on the stretch of chromosome 5 found faulty in many people with leukemia.
BMT is indicated in certain cases of preleukemia, multiple myeloma, Hodgkin's disease, and non-hodgkin's lymphomas.
Rowley, "Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome," Blood, vol.
Roberts, 51, who previously battled breast cancer in 2007, announced in early June that she had been diagnosed with a rare disorder called myelodysplastic syndrome, known in the past as preleukemia. In spite of her diagnosis, Roberts' assured fans that her health issues would not prevent her from continuing on with her regular schedule.
Because atypical Sweet's is associated with preleukemia, leukemia, lymphoma, and some solid tumors, these patients should have a complete blood count to identify hematologic abnormalities.