Prolonged dosing resulted in continued spermatocyte degeneration as well as maturation depletion of the spermatid population, leaving tubules containing only sustentacular cells, spermatogonia and preleptotene
Round spermatids, spermatocytes in preleptotene
and pachytene stages, nuclei of Sertoli cells, and type A and type B spermatogonia were also observed in this stage.
Tight junction not only establishes a specialized microenvironment for spermatogenesis but also permits the regular passage of preleptotene
and leptotene spermatocytes across the BTB for further development .
In all mammals, the type B/B1 spermatogonia undergo mitosis to give rise to the cells that represent the beginning of meiosis, the preleptotene
The spg are located on the basal membrane; above these, many spcI in different stages of the meiotic prophase from preleptotene
, pachytene, diplotene until diakinesis are easily recognizable according to the aspect of thechromatin.
(46) FSH is responsible for the development and differentiation of spermatogonia through different stages namely spermatogonia, preleptotene
, leptotene, early pachytene, late pachytene, and secondary spermatocytes after the attainment of puberty.
Under normal physiological conditions, the primary spermatocyte (in preleptotene
) migrates through the junctions of the Sertoli cells from the basal membrane to the tubules intraluminal compartment.
In meiosis the process is divided into six stages: preleptotene
, leptotene, zygotene, pachytene, diplotene, and diakinesis.
Population of preleptotene
, pachytene, secondary spermatocytes and step-19 spermatid were declined by 60.86%, 65.81%, 71.56% and 66.55%, respectively.
[+ or -] [+ or -] Paniculata 0.10 0.13 stem fraction (50:50) CH[Cl.sub.3]: C[H.sub.3]OH 50 mg/rat/day (Percent (-44.89%) (-36.84%) deviation) (c) Testicular cell counts (number/10 cross section) Primary spermatocytes Preleptotene
Pachytene Group-I 19.79 34.62 control [+ or -] [+ or -] (Vehicle 1.95 1.98 treated) Group-II 3.92 ** 3.39 ** M.
The most susceptible cells were actively dividing spermatogonium and spermatocytes up to preleptotene
The population of preleptotene
and pachytene spermatocytes were decreased by 64.26% and 55.13% respectively.