prekallikrein


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Related to prekallikrein: High molecular weight kininogen

prekallikrein

 [pre-kal″ĭ-kre´in]
a plasma protein that is the proenzyme of plasma kallikrein; it is cleaved to its active enzyme form by activated coagulation factor XII.

pre·kal·li·kre·in

(prē'kal-ĭ-krē'in),
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII. Prekallikrein also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor

pre·kal·li·kre·in

(prē'kal-i-krē'in)
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII; also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor.

Fletcher,

surname of the patient in whom the defect was first noted.
Fletcher defect - slow contact activation in coagulation of the blood.
Fletcher factor - factor found in coagulation studies, revealing a slow contact activation but not associated with bleeding abnormalities. Synonym(s): prekallikrein

pre·kal·li·kre·in

(prē'kal-i-krē'in)
A plasma glycoprotein that in complex with kininogen serves as a cofactor in the activation of factor XII; also serves as the proenzyme for plasma kallikrein.
Synonym(s): Fletcher factor.
References in periodicals archive ?
However, for any given DIC stimulus, more than one activation pathway may be involved (see Table 4).[6,7] When endothelial cells are damaged, the exposed collagen activates FXII, which stimulates the intrinsic pathway and converts prekallikrein to kallikrein to activate fibrinolysis.
Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor dependent pathways," Journal of Clinical Investigation, vol.
Basically, aPTT is affected by the activities of clotting factors XII, XI, X, IX, VIII, V, II, and I, as well as by high molecular weight kininogen and prekallikrein. Measuring the PT and the thrombin time (TT) can efficiently narrow the number of required analyses.
Activated factor XII converts prekallikrein into kallikrein, and the latter cleaves high-molecular-weight kininogen into bradykinin, which mediates many of the biologic effects of this system.
An isolated result showing aPTT prolongation suggests a deficiency or inhibitor of one or more of the intrinsic pathway clotting factors (prekallikrein, high molecular weight kininogen, factors XII, XI, IX, and VIII).
Fibrinogen Vitamin K-dependent Contact Fibrinogen Factor II Factor XII Factor V Factor VII HMWKa Factor VIII Factor IX Prekallikrein (b) Factor XIII Factor X Factor XI (a) HMWK, high-molecular weight kininogen, also known as Fitzgerald factor.