preimplantation genetic diagnosis


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preimplantation genetic diagnosis (PGD)

in assisted reproductive technology, the determination of chromosomal abnormalities in the embryo before it is transferred to the uterus.

preimplantation genetic diagnosis

In assisted reproduction, the testing of a fertilized egg for heritable illnesses before the ovum is inserted into the female.
See also: diagnosis

preimplantation genetic diagnosis

The use of genetic analysis in the course of vitro fertilization to ensure that a baby does not possess a known genetic defect of either parent. After analysis of the embryos formed, only those free of defect are implanted in the mother's womb. A new method, developed in 2006, involves taking a single cell from the IVF embryo, amplifying the entire genome to provide many copies, and then comparing the chromosome containing the known family mutation with those of other family members by standard DNA fingerprinting techniques.
References in periodicals archive ?
Preimplantation genetic diagnosis (PGD) is widely accepted as a means to weed out embryos with genetic disorders.
I have not yet heard such an argument made about preimplantation genetic diagnosis, but it would not surprise me to hear some bioethicist worry more about whether the Alzheimer's-gene-free child could have consented to PGD than about the pain and suffering this child will endure when her mother disintegrates before her eyes.
Biopsy on day 5 at the blastocyst stage is potentially less invasive to the embryo than the standard day-3 biopsy used in preimplantation genetic diagnosis.
If the parents opt for testing, they must use either prenatal diagnosis followed by selective abortion (if the fetus is not one they want to bring to term), or preimplantation genetic diagnosis and selective transfer of embryos (to ensure that they have a fetus they want to bring to term).
The announcement was made by researchers at Genetics Institute, best known for pioneering the technique called preimplantation genetic diagnosis (PGD), which tests human embryos created in the lab before they are implanted in the womb.
Dr Wells and Prof Delhanty also believe their test could be used for preimplantation genetic diagnosis for couples at high risk of passing on serious inherited conditions.
One such advancement, preimplantation genetic diagnosis (PGD), is an important addition to successful fertility treatments, and is being supported by ARC Fertility, the largest network of fertility specialists in the county.
Their report concludes that, "The staining of spermatozoa with specific markers and sorting with flow cytometry provides a means of preventing significant disease in the offspring and may help in reducing the number of surplus embryos needed for preimplantation genetic diagnosis.
DENVER - Utilization of preimplantation genetic diagnosis in the United States shows substantial and as-yet unexplained regional variation, according to the first-ever national analysis.
Should preimplantation genetic diagnosis be used to avoid inheritance of early-onset Alzheimer's disease?
In 1999, the Ethics Committee of the American Society for Reproductive Medicine had concluded that couples should be discouraged from undergoing IVF with preimplantation genetic diagnosis (PGD) solely to choose the gender of offspring.