pregnane


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pregnane

 [preg´nān]
a crystalline saturated steroid hydrocarbon; β-pregnane is the form from which several hormones, including progesterone, are derived; α-pregnane is the form excreted in the urine.

preg·nane

(preg'nān),
Parent hydrocarbon of two series of steroids stemming from 5α-pregnane (originally allopregnane) and 5β-pregnane (17β-ethyletiocholane). 5β-Pregnane is the parent of the progesterones, pregnane alcohols, ketones, and several adrenocortical hormones and is found largely in urine as a metabolic product of 5β-pregnane compounds.

preg·nane

(preg'nān)
Parent hydrocarbon of the progesterones, pregnane alcohols, ketones, and several adrenocortical hormones.
Compare: bioregulator
References in periodicals archive ?
Caralluma extract contains pregnane glycosides which are responsible for blocking the activity of citrate lyase, thus, inhibiting fat synthesis and faster burning of fat.
These nuclear receptors include the Farnesoid X receptor (FXR), the Pregnane X receptor (PXR), G-protein coupled receptors (GPCR) and the Vitamin D receptor (VDR).
Three docking case studies were presented: a) the aryl hydrocarbon receptor, which mediates toxicity induced by many environmental contaminants; b) hypoxia inducible factor 2a, a transcription factor that is a possible target of anti-tumor agents; and c) the pregnane X receptor, a nuclear receptor target of drugs.
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane x receptor.
Sethi, Synthesis, crystal structure, conformational analysis, nonlinear optical property and computational study of novel pregnane derivatives, J.
Likewise, these endocrine disruptors may exhibit their activities by altering pregnane X receptor-regulated (PXR) steroid hormone metabolism [8].
This is because azoles exert an influence on the transcriptional activity of the pregnane X receptor (PXR) by modulating its ligand-binding properties or by affecting the recruitment of co-activators (32).
John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.
The serial domestic abuser had previously been jailed for controlling and violent behaviour against his last two partners - locking one of them in her home and threatening to kill another woman while she was 16 weeks pregnane with his child.
Genus Caralluma enriched in pregnane glycosides, megastigmane glycosides, flavone and esters (Adnan et al., 2014).

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