pregnane

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pregnane

[preg´nān]

a crystalline saturated steroid hydrocarbon; β-pregnane is the form from which several hormones, including progesterone, are derived; α-pregnane is the form excreted in the urine.

preg·nane

(preg'nān),

Parent hydrocarbon of two series of steroids stemming from 5α-pregnane (originally allopregnane) and 5β-pregnane (17β-ethyletiocholane). 5β-Pregnane is the parent of the progesterones, pregnane alcohols, ketones, and several adrenocortical hormones and is found largely in urine as a metabolic product of 5β-pregnane compounds.

Farlex Partner Medical Dictionary © Farlex 2012

preg·nane

(preg'nān)

Parent hydrocarbon of the progesterones, pregnane alcohols, ketones, and several adrenocortical hormones.
Compare: bioregulator

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

References in periodicals archive ?

Caralluma extract contains pregnane glycosides which are responsible for blocking the activity of citrate lyase, thus, inhibiting fat synthesis and faster burning of fat.

Caralluma Extract Market Revenue, Opportunity, Forecast and Value Chain 2018 to 2028

These nuclear receptors include the Farnesoid X receptor (FXR), the Pregnane X receptor (PXR), G-protein coupled receptors (GPCR) and the Vitamin D receptor (VDR).

Functional Gastroenterology Bolus

Three docking case studies were presented: a) the aryl hydrocarbon receptor, which mediates toxicity induced by many environmental contaminants; b) hypoxia inducible factor 2a, a transcription factor that is a possible target of anti-tumor agents; and c) the pregnane X receptor, a nuclear receptor target of drugs.

Use of Alternative Methods: From Fundamental to Industrial Research

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane x receptor.

Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis

Sethi, Synthesis, crystal structure, conformational analysis, nonlinear optical property and computational study of novel pregnane derivatives, J.

Facile Synthesis, Crystal Growth, Quantum Chemical Studies of Electronic Structure and of the Profoundly Persuasive NLO Organic Crystal: Ethyl 4-[N,N-bis(p-toluenesulfonyl)]-Aminobenzoate

Diasteranes and pregnane are also present in low abundances.

BIOMARKER CHARACTERIZATION OF VARIOUS OIL SHALE GRADES IN THE UPPER CRETACEOUS QINGSHANKOU FORMATION, SOUTHEASTERN SONGLIAO BASIN, NE CHINA

Likewise, these endocrine disruptors may exhibit their activities by altering pregnane X receptor-regulated (PXR) steroid hormone metabolism [8].

ENVIRONMENTAL NON-PERSISTENT ENDOCRINE-DISRUPTING CHEMICALS EXPOSURE AND REPRODUCTIVE HORMONES LEVELS IN ADULT MEN

This is because azoles exert an influence on the transcriptional activity of the pregnane X receptor (PXR) by modulating its ligand-binding properties or by affecting the recruitment of co-activators (32).

Fundamental Concepts of Azole Compounds and Triazole Antifungals: A Beginner's Review

John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.

Protective effects of St. John's wort in the hepatic ischemia/reperfusion injury in rats

Bisphenol A and its analogues activate human pregnane X receptor.

Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood

The serial domestic abuser had previously been jailed for controlling and violent behaviour against his last two partners - locking one of them in her home and threatening to kill another woman while she was 16 weeks pregnane with his child.

Thug's acid attack threat

Genus Caralluma enriched in pregnane glycosides, megastigmane glycosides, flavone and esters (Adnan et al., 2014).

ANTI-INFLAMMATORY EFFECT OF CARALLUMA EDULIS AGAINST ACUTE AND CHRONIC INFLAMMATION