, physical activity is commonly associated with increased endogenous opioid peptides, and increased [micro]-opioid receptors have been reported in the rat hippocampus following acute and chronic exercise .
Detection of preclinically
latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients.
FTS is used preclinically
to evaluate and screen antidepressant effect of drugs or other treatments in rodents [22, 23].
coli isolated from apparently healthy birds is perhaps due to the fact that these birds were infected but preclinically
affected or their environments contained a heavy load of APEC which passed through the birds without causing infection.
Immunoediting has been demonstrated preclinically
in murine models of sarcoma .
Neuroblastoma of the urinary bladder, preclinically
detected by mass screening.
Ambrx ADCs have preclinically
demonstrated high potency and a wider therapeutic index than ADCs created using conventional nonspecific conjugation.
NMTMB and compound A are confirmed multiorgan in vivo phospholipogenics as they were tested preclinically
in both rat and dog models (data not shown).
"We believe these preliminary clinical findings corroborate the advantage of pretargeting we have observed preclinically
over traditional antibody-directed radiation therapy in the delivery of higher therapeutic doses to tumor sites without simultaneously raising the toxicity profile of the treatment," commented Cynthia L.
SNOWMASS, COLO.--One of the most interesting questions in all of rheumatology is this: Where does rheumatoid arthritis hang out in the body preclinically
during the years following autoantibody formation but before symptomatic joint involvement?
detected antidiabetic effects of bitter melon have to be analyzed in the scope of well-designed human studies.
, trastuzumab has synergistic activity when combined with a variety of chemotherapy drugs, perhaps because it inhibits an important survival pathway making the cytotoxic effects of chemotherapy more potent.