preclinical toxicology


Also found in: Acronyms.

preclinical toxicology (prēˈ·kliˑ·ni·kl tksˈ··kˑ·l·jē),

n studies of the toxicology of a substance on animals and cells to prepare parameters for Phase I human subject clinical studies. These include determination of acute, subacute, and chronic toxicity, carcinogenicity, mutagenicity, teratogenicity, and effects on the reproductive system.
References in periodicals archive ?
Visterra said that the BARDA contract includes funding for performing preclinical toxicology studies, conducting clinical trials, manufacturing of materials for clinical trials and continued optimization of manufacturing processes, and associated regulatory activities intended to advance VIS410.
Biotechnology company Synthetic Biologics (NYSE MKT:SYN) said on Tuesday that it has received encouraging results from its final preclinical toxicology study of SYN-004 to prevent the devastating effects of Clostridium difficile (C.
Steve Snyder is a consultant with more than 25 years of experience in preclinical toxicology as an outsourcing customer and provider.
Conduct of successful preclinical toxicology trials on CSSK in cynomolgus monkeys.
By Steve Snyder Contributing Editor Steve Snyder is a consultant with more than 25 years of experience in preclinical toxicology as an outsourcing customer and provider.
PM060184 is a marine-derived synthetically-produced compound which has shown strong in vitro and in vivo antitumor activity and a favorable safety profile in preclinical toxicology studies.