preclinical study

preclinical study

Any of the animal studies that provide the science behind human Phase-1 safety and tolerance studies, which must comply with good laboratory practice (GLP).

Data about a drug's activities and effects in animals informs boundaries for safe use of the drug in subsequent human testing (clinical studies or trials).
References in periodicals archive ?
The Phase 1 and preclinical study results demonstrate that the TLR7 agonists vesatolimod and GS-986 can induce immune activation and follow earlier preclinical research suggesting that TLR7 agonists can potentially lead to viral remission, as part of combination regimens.
In this preclinical study in spontaneously diabetic obese cynomolgus monkeys, the product indicated statistically significant pharmacodynamic effects on key metabolic and liver parameters associated with NASH following weekly and every two-week subcutaneous dosing.
Confirmation of aMSC-based seeding was performed, and anesthetized pigs underwent full thickness circumferential resection of a length of the esophagus in the ongoing preclinical study.
8 September 2016 - US-based healthcare market IT solutions company Instem has acquired French preclinical study software specialist Notocord, the company said.
(NASDAQ: CYTX) announced today the publication of a preclinical study applying Adipose-Derived Regenerative Cells (ADRCs) prepared using Cytori Cell Therapy in a large animal model of urethral injury.
Having plans to mitigate risk is essential for any preclinical study regardless of the location where the study is conducted.
NORDIC BUSINESS REPORT-April 4, 2011--Norwegian Algeta to present preclinical study with Alpharadin in breast cancer(C)2011 M2 COMMUNICATIONS http://www.m2.com
Preclinical study results suggest that CV Therapeutics' proprietary biopolymer stent coating technology could potentially improve the performance of stents coated with drugs such as paclitaxel or rapamycin by potentially limiting cracking and peeling following implantation of the stent.
The results of this preclinical study, said Enzo, demonstrate that Enzo's immune enhancement regulation technology could be effective in negating the effects of GvHD by enhancing the anti-inflammatory immune response mounted by the donor tissue or cells.
The 20-week preclinical study compared the activity of CB 2679d-GT with that of an AAV-encoding FIX-R338L Padua in hemophilia B mice.
Alpine presented the results of a preclinical study of ALPN-202 in a poster session, strongly supporting the proposed mechanism of action of ALPN-202 via activation of the immune system in a differentiated way from current checkpoint therapies.