Spinraza alters the splicing of SMN2 pre-mRNA
in order to increase production of full-length SMN protein.
The paper 'Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA
to determine profibrotic or antifibrotic cell phenotype' is published in the journal Science Signalling.
recent advances in the field have shown that, Not only does as regulation rely on the recruitment of various splicing factors to the pre-mrna
, But other phenomena such as rna polymerase ii elongation rate, Histone post-translational modifications or long non-coding rnas have been shown to regulate this process.
Up until now, it is known that OCT4 pre-mRNA
can produce various splice variants such as OCT4A, OCT4B, OCT4B1 and also OCT4B2 under different situations (3,4).
Eteplirsen is designed to bind to exon 51 of dystrophin pre-mRNA
, resulting in exclusion of this exon during mRNA processing in patients with genetic mutations that are amenable to exon 51 skipping.
PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA
Splicing," Cell Reports, 2016; 17 (10): 2766 DOI: 10.
This viral polymerase, using a specific "cap-snatching" mechanism utilizes host pre-mRNA
as a primer for transcription of viral mRNA.
2006 pXBP1(U encoded in XBP1 pre-mRNA
negatively regulates unfolded protein response activator pXBP1(S in mammalian ER stress response.
Characterization of an intron splice enhancer that regulates alternative splicing of human GH pre-mRNA
U2af1 is a small subunit of the U2 small nuclear ribonucleoprotein auxiliary factor that contains CCCH domains and has an important function in the regulation of pre-mRNA
splicing (Kanadia et al.
In vitro experiment has shown p68 to be essential for splicing of pre-mRNA
(Liu 2002) and it participates in regulation of alternative splicing of c-H-ras (Guil et al.
Furthermore, FUS is implicated in the regulation of gene promoter activity (17), is involved in pre-mRNA
splicing (18), and shuttles between the nucleus and the cytoplasm bound to RNA (19).