pre-eclampsia

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eclampsia/pre-eclampsia

(From Greek eklampsis, shining forth) Metabolic toxemia of pregnancy Obstetrics A condition which usually develops in late pregnancy or the immediate puerperium Clinical HTN, hemoconcentration, sodium retention with resultant edema Lab Albuminuria, proteinuria, hypoproteinemia, ↑ nitrogen/BUN; pre-eclampsia is most common in primigravidas, after the 24th gestational wk, but may occur as soon as trophoblastic tissue is present Treatment If mild, bed rest and sedation; if severe, antihypertensives–eg, vasodilators, α methyldopa; if convulsions, magnesium sulfate. See HELLP syndrome.

pre-eclampsia

A syndrome of high blood pressure (HYPERTENSION), fluid accumulation in the tissues (OEDEMA) and protein in the urine (albuminuria) that becomes apparent in the second half of pregnancy. Pre-eclampsia is primarily a placental disorder with damage to the inner lining (endothelium) of placental blood vessels. Oxygen FREE RADICALS cause endothelial cell damage, and may lead to reduced NITRIC OXIDE production, so that blood vessel widening (vasodilatation) is interfered with. Pre-eclampsia is a warning of the dangerous complication of ECLAMPSIA-a condition of seizures carrying a high maternal and fetal mortality. A major reason for antenatal care is to monitor for pre-eclampsia and to treat the condition, induce labour or perform a Caesarean section. It has been shown that abnormally high levels of circulating angiogenic factors such as vascular endothelial growth factor and soluble fms-like tyrosine kinase 1 predict the development of pre-eclampsia.
References in periodicals archive ?
An earlier study conducted on pre-eclamptic patients revealed that those with sFlt-1/PlGF ratios < 85 are more likely to be correlated with those women predisposed to obesity, pre-existing diabetes, and limited serious adverse outcomes, than those with sFlt-1/PlGF ratios >85 (65).
Receiver operating characteristic curves were applied to check the diagnostic value of T2* in the estimation of pre-eclamptic placentas and the best T2* cutoff value, which represents the diagnosis of pre-eclampsia.
van Asshe, "A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies," The British Journal of Obstetrics and Gynaecology, vol.
"With both the mother and the father passing on their variant genes to their children, this places the child at greater risk of parenting a pre-eclamptic pregnancy."
The purpose of this registry-based study was to compare the obstetric outcomes in primiparous and pre-eclamptic women younger and older than 35 years.
However, majority of the pre-eclamptic women do not suffer from any underlying medical conditions.
In a normal pregnancy, angiogenesis, and vascular transformation lead to normal placental development, whereas pre-eclamptic pregnancies are subject to abnormal angio-genesis and vascular transformation.
The initiation of LMWH therapy is typically used in patients already in higher risk morbidity categories such as those with heparin sensitivity issues, those with described clotting diatheses, in higher risk pregnancies (antiphospholipid antibody patients, pre-eclamptic), and patients with histories of hypercoagulable states.
Three case-control studies compared normotensive women with pregnancy-induced hypertension or pre-eclamptic women for the presence of obstructive sleep apnoea (105-107).
The mean pocket depth and missing teeth for pre-eclamptic patients were not significantly as compared with those of normotensive patients (Table I).
(15.) YITZHAK M, BAR J, MAZOR M, FRAZER D, et al: Increased rate of small-for-gestational-age neonates in pre-eclamptic women preterm deliveries.