pre-eclampsia


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eclampsia/pre-eclampsia

(From Greek eklampsis, shining forth) Metabolic toxemia of pregnancy Obstetrics A condition which usually develops in late pregnancy or the immediate puerperium Clinical HTN, hemoconcentration, sodium retention with resultant edema Lab Albuminuria, proteinuria, hypoproteinemia, ↑ nitrogen/BUN; pre-eclampsia is most common in primigravidas, after the 24th gestational wk, but may occur as soon as trophoblastic tissue is present Treatment If mild, bed rest and sedation; if severe, antihypertensives–eg, vasodilators, α methyldopa; if convulsions, magnesium sulfate. See HELLP syndrome.

pre-eclampsia

A syndrome of high blood pressure (HYPERTENSION), fluid accumulation in the tissues (OEDEMA) and protein in the urine (albuminuria) that becomes apparent in the second half of pregnancy. Pre-eclampsia is primarily a placental disorder with damage to the inner lining (endothelium) of placental blood vessels. Oxygen FREE RADICALS cause endothelial cell damage, and may lead to reduced NITRIC OXIDE production, so that blood vessel widening (vasodilatation) is interfered with. Pre-eclampsia is a warning of the dangerous complication of ECLAMPSIA-a condition of seizures carrying a high maternal and fetal mortality. A major reason for antenatal care is to monitor for pre-eclampsia and to treat the condition, induce labour or perform a Caesarean section. It has been shown that abnormally high levels of circulating angiogenic factors such as vascular endothelial growth factor and soluble fms-like tyrosine kinase 1 predict the development of pre-eclampsia.
References in periodicals archive ?
The eclampsia group had more number of aged mothers, primigravida with generalised and pedal oedema and also proteinuria, whereas mothers with severe pre-eclampsia and mild pre-eclampsia were in the lower age group with or without pedal oedema and proteinuria, Table 2.
The trial of 1,776 women at high risk for pre-term pre-eclampsia found a lower incidence of developing the disease in women taking aspirin than those taking a placebo.
A spokeswoman for Birmingham Women's and Children's NHS Foundation Trust said: "Despite a delay in sending off Chardonnay La'More's blood samples, we did everything we could from the moment we suspected she had pre-eclampsia.
Keywords: Diastolic, doppler, notch, pre-eclampsia, prenatal, ultrasonography, uterine arteries.
This case-control study was conducted on 50 consecutive Iranian women suffering from pre-eclampsia with a gestational age of 18 to 22 weeks, who were selected from the patients referring to prenatal clinic of Valiasr Hospital for routine check-up from April 2013 to March 2014.
The report reviews pipeline therapeutics for Pre-Eclampsia by companies and universities/research institutes based on information derived from company and industry-specific sources
uk/researchstrategy LOUISE DODD MOTHER-OF-TWO Louise Dodd was diagnosed with pre-eclampsia in pregnancy and was rushed to hospital where she had to undergo an emergency section.
Comparison between pre-eclampsia group and normal group was done by unpaired t-test.
KEY WORDS: Pre-eclampsia, Pregnancy; Estrogen receptor alpha; Polymorphism.
Now, researchers from the University of Missouri, in an effort to grow placenta cells to better study the causes of pre-eclampsia, serendipitously discovered a previously unknown form of human embryonic stem cell.
There are still gaps in our knowledge of pre-eclampsia but we do know that it only occurs in pregnancy or shortly after birth.
Pre-eclampsia is found in 3-10% of pregnancies worldwide and remains a major cause of maternal and foetal morbidity and mortality.