pre-eclampsia


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eclampsia/pre-eclampsia

(From Greek eklampsis, shining forth) Metabolic toxemia of pregnancy Obstetrics A condition which usually develops in late pregnancy or the immediate puerperium Clinical HTN, hemoconcentration, sodium retention with resultant edema Lab Albuminuria, proteinuria, hypoproteinemia, ↑ nitrogen/BUN; pre-eclampsia is most common in primigravidas, after the 24th gestational wk, but may occur as soon as trophoblastic tissue is present Treatment If mild, bed rest and sedation; if severe, antihypertensives–eg, vasodilators, α methyldopa; if convulsions, magnesium sulfate. See HELLP syndrome.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

pre-eclampsia

A syndrome of high blood pressure (HYPERTENSION), fluid accumulation in the tissues (OEDEMA) and protein in the urine (albuminuria) that becomes apparent in the second half of pregnancy. Pre-eclampsia is primarily a placental disorder with damage to the inner lining (endothelium) of placental blood vessels. Oxygen FREE RADICALS cause endothelial cell damage, and may lead to reduced NITRIC OXIDE production, so that blood vessel widening (vasodilatation) is interfered with. Pre-eclampsia is a warning of the dangerous complication of ECLAMPSIA-a condition of seizures carrying a high maternal and fetal mortality. A major reason for antenatal care is to monitor for pre-eclampsia and to treat the condition, induce labour or perform a Caesarean section. It has been shown that abnormally high levels of circulating angiogenic factors such as vascular endothelial growth factor and soluble fms-like tyrosine kinase 1 predict the development of pre-eclampsia.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Pre-eclampsia is a condition that affects around 1 in 20 pregnant women, usually during the second half of pregnancy affecting approximately 40,000 women annually in the UK.
They also found that the women in that group had more vaginal deliveries compared to those who experience the current method of care - specialist assessment of mother and unborn baby until 37 weeks, with delivery sooner if the clinical scenario changes and there is concern over severe pre-eclampsia and associated complications.
Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: A systematic review and bivariable meta-analysis.
A study involved 1,035 women with suspected pre-eclampsia at 11 hospitals across the UK and showed the average time to pre-eclampsia diagnosis was cut from 4.1 days to 1.9 days, plus serious complications for the mother were also cut.
"About one in six women who've had pre-eclampsia will get it again in a future pregnancy.
About 10% of pregnant patients are at high risk of developing pre-eclampsia, eclampsia and its prevalence is high in developing countries.
Increased plasma levels of the novel vasoconstrictor peptide endothelin in severe pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 1991;40:215-20.
However, because the headache and related symptoms of pre-eclampsia and migraine overlap, close follow-up with monitoring for signs of pre-eclampsia is necessary.
| For more information on pre-eclampsia or pregnancy go to nhs.uk
These views were expressed by the noted gynecologist speakers while addressing the first symposium on recent updates in Pathogeneses of Pre-Eclampsia hosted by the Department of Biochemistry-Institute of Basic Medical Sciences Khyber Medical University (KMU) Peshawar here on Friday.