CARE calismasinda pravastatin
alan grupta, inme riskinde %31 oraninda anlamli azalma izlenmis, bu faydanin da antitrombosit ilaclarin sagladigi azalmaya ilave olarak gelistigi dusunulmustur.
The hypothesis was that pravastatin
would slow age-related cognitive decline in these patients, all of whom had good cognitive function at baseline as evidenced by a Mini-Mental Status Exam score above 24.
And that fits with the results of the Cholesterol and Recurrent Events (CARE) trial, which was designed to see whether pravastatin
could lower the risk of a second heart attack.
This man volunteers no history of intestinal upset and denies poor dietary habits, 2 areas that need assessment given the finding of weight loss while on 5 new drugs (4 antiretrovirals and pravastatin
(3) The study authors used the incidence of new diabetes in patients taking pravastatin
as the baseline, since it had been associated with reduced rates of diabetes in a large cardiovascular prevention trial.
Importantly, it may not reduce the cholesterol all the way to an acceptable range and you may still have to take the pravastatin
. So be sure to check the cholesterol level again when your thyroid status returns to normal.
For this study, we selected pravastatin
, which is thought to have a strong antiinflammatory action (6).
Statins are li pid-lowering drugs by c ompeti ti vely inhibiting 3-hydroxy-3-methyl-glutar yl-coenz yme A reductase enzyme (HMGCR) and thus limiting cholesterol biosynthesis.1 Statins are administered daily as standard therapy for primary and s eco ndar y prevention of coronary heart disease (CHD), stroke and peripheral ar terial disease (PAD).2 Commonly used statins are rosuvastatin, atorvastatin, fluvastatin, lovas tatin, simvastatin, pravastatin
To the Editor: We appreciated the attentive and interesting paper by Huai et al . on the protective effects of pravastatin
on preeclampsia (PE)-like effects in mouse models.
Moderate-intensity statin I therapy (with pravastatin
or simvastatin) doesn't prevent progression to dementia in patients at increased risk.
The investigators confined their analysis to the four most commonly prescribed statins: simvastatin, atorvastatin, pravastatin
(30) to determine the mean percent change from baseline for lovastatin (10, 20, 40, and 80 mg), pravastatin
(10, 20, and 40 mg), simvastatin (5, 10, 20, 40, and 80 mg), atorvastatin (10, 20, 40, and 80 mg), fluvastatin (20 and 40 mg), rosuvastatin (5, 10, 20, and 40 mg), and ezetimibe (10 mg; all daily doses).