pragmatic trial


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pragmatic trial

A clinical trial that measures effectiveness (i.e., the degree of beneficial effect of a drug or intervention in real clinical practice) by testing a full range of patients—with variable compliance, co-morbidities and polypharmacy—who might be treated with the drug or intervention. If an intervention has a significant beneficial effect in a pragmatic trial, then it has been shown not only that it can work, which reflects the results of a so-called explanatory trial, but also that it does work.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

pragmatic trial

A trial to evaluate the effectiveness of a treatment investigated under real-world conditions, rather than during the application of stringent exclusion criteria.
See also: trial
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
For the reader it may be helpful to think of a sliding scale, moving from a highly controlled explanatory trial to a clinically-orientated pragmatic trial.
(Pragmatic trials are designed to reflect "real-world" medical care by recruiting broad populations of patients, embedding the trial into the usual healthcare setting and leveraging data from health systems to produce results that can be readily used to improve patient care.)
Likely what is needed is an "all of the above" approach: more pragmatic trials to evaluate proven therapies and their combinations in real-world settings; efforts to reduce the use of low-value services, such as payer coverage policies based on guideline recommendations; patient engagement through shared decision making; and pressure on insurers to cover nonpharmacologic, noninvasive therapies that have shown benefit.
If pragmatic trials or high-quality prospective observational studies are completed and published over the next decade, an improved evidence base may help clinicians and public health planners decide on the most appropriate use of oseltamivir and potential new influenza antiviral agents for patients with severe infections caused by seasonal or pandemic influenza.
For instance, the Knowledge Translation Unit at the University of Cape Town has conducted pragmatic trials evaluating outreach education and task shifting of care from doctors to other health professionals, compared with standard care for implementing guidelines for respiratory conditions, including tuberculosis and more recently HIV.
Other prerequisites for real-world pragmatic trials are scientific excellence, therapy area expertise, the scope and scale of operations to efficiently execute studies, expertise in clinical trial design and health economics and outcomes research (HEOR), as well as a knowledge of related regulatory requirements and guidelines.
Two pragmatic trials of treatment for shoulder disorders in primary care, general ability, course, and prognostic indicators.
preference trials, pragmatic trials) methods and designs for health intervention research.
to give appropriate weight to health services methods such as pragmatic trials and observations methods," according to Wardle and Oberg.
DaVita Clinical Research uses its applied database and healthcare experience to assist pharmaceutical and medical device companies in the design, recruitment, and completion of clinical trials including retrospective and prospective pragmatic trials.
cluster trials, non-inferiority and equivalence trials, and pragmatic trials), interventions (i.e.