DOK1

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DOK1

A gene on chromosome 2p13 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK1 modulates integrin activation by competing with talin for the same binding site on ITGB3, and may be a negative regulator of the insulin signalling pathway. It is expressed in the pancreas, heart, leukocytes and spleen.
References in periodicals archive ?
The 2015 budget for the 4P's was P15.4 billion more than its 2014 budget, which amounted to PP62.6 billion.
Out of the Box Publishing, 2014, pp62, 5.99[pounds sterling]
(58.) Lane, Soviet Society under Perestroika, p354; Izvestiia, 1 March 1991, p2, in Lapidus, 'From democratisation to disintegration', pp62, 69.
Aschheim, Scholem, Arendt, Klemperer: Intimate Chronicles in Turbulent Times, Bloomington, Indiana University Press, 2001, pp62, 67.