RB1

(redirected from pp110)

RB1

A gene on chromosome 13q14.2 that encodes a tumour suppressor protein which is a key regulator of entry into cell division, promoting G0-G1 transition following phosphorylation by CDK3/cyclin-C. RB1 represses transcription of E2F1 target genes. Underphosphorylated,
active forms of RB1 interact with E2F1 and repress its transcription activity, leading to cell cycle arrest. With calcium influx, RB1 is dephosphorylated by calcineurin, leading to release of the repressor complex.  

Molecular pathology
Defects in RB1 cause childhood retinoblastoma, some forms of osteogenic sarcoma and increased susceptibility to bladder cancer.
References in periodicals archive ?
Specifically, gambling was investigated across four percentage-payback levels: 50%, 75%, 95%, and 110% (corresponding condition names were PP50, PP75, PP95, and PP110, respectively).
Lastly, these participants experienced the PP110 condition only once, near the end of the experiment.
When the condition changed to PP110, total trials decreased to 36 but then increased quickly over the next three sessions to 103 total trials.
Alternatively, under PP110 conditions, there was no such relationship between total trials completed and credits remaining.