RB1

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RB1

A gene on chromosome 13q14.2 that encodes a tumour suppressor protein which is a key regulator of entry into cell division, promoting G0-G1 transition following phosphorylation by CDK3/cyclin-C. RB1 represses transcription of E2F1 target genes. Underphosphorylated,
active forms of RB1 interact with E2F1 and repress its transcription activity, leading to cell cycle arrest. With calcium influx, RB1 is dephosphorylated by calcineurin, leading to release of the repressor complex.  

Molecular pathology
Defects in RB1 cause childhood retinoblastoma, some forms of osteogenic sarcoma and increased susceptibility to bladder cancer.
References in classic literature ?
The villa had been repainted and decorated, and it looked fresher, and even, to their preoccupied minds, appeared more attractive than ever.
The family had moved; they had not been able to pay the rent and they had been turned out into the snow, and the house had been repainted and sold again the next week.
For this sum he repainted the box, traced her initials on it, and affixed new hinges, a Bramah lock, and brass handles, at a cost to himself of ten shillings and several hours' labor.
The squire had had everything repaired, and the public rooms and the sign repainted, and had added some furniture--above all a beautiful armchair for mother in the bar.
I said good-bye to Mother and the cove where I had lived since I was born, and the dear old Admiral Benbow--since he was repainted, no longer quite so dear.
In spite of all the efforts of the poor old man, sundry twitchings and screwings of the muscles of the face denoted the exquisite sensibility of these shutters to the windows of his soul, which he was now having repainted.
The landlord had repainted it when Strickland took the bungalow, and unless you knew how Indian bungalows were built you would never have suspected that above the cloth lay the dark, three- cornered cavern of the roof, where the beams and the under side of the thatch harbored all manner of rats, hats, ants, and other things.
He had our boat out of the water, cleaned and repainted its bottom, made a trifling alteration about the centre-board, overhauled the running gear, and sat up nearly all of Saturday night sewing on a new and much larger sail.
Alice looked up at the Rocking-horse-fly with great interest, and made up her mind that it must have been just repainted, it looked so bright and sticky; and then she went on.
It is said that he once repainted all the numbers in a street in the dead of night merely to divert one traveller into a trap.
In all he had painted and repainted he saw faults that hurt his eyes, coming from want of care in taking off the wrappings--faults he could not correct now without spoiling the whole.
The room was so far changed that it was papered now, and had been repainted, and was far more comfortably furnished; but he could recall it just as he had seen it in that single glance, when he raised her from the ground and carried her down to the carriage.