ENPNewswire-August 1, 2019--Atlantic Healthcare Announces Results from Phase 3 Trial of Alicaforsen Enema for Orphan-Designated
PouchitisOral bacteriotherapy as maintenance treatment in patients with chronic
pouchitis: a double-blind, placebo-controlled trial.
This approach is being evaluated by Alivio internally across a variety of inflammatory diseases, including IC/BPS,
pouchitis, and inflammatory bowel disease.
For ulcerative colitis and
pouchitis, Webb suggests VSL#3, which is a multi-strain probiotic.
The firm will also postpone its decision about the start of a Phase two/ three clinical trial of PTG-100 in chronic
pouchitis until after its autumn review of the interim data from the UC PROPEL study.
Additionally, the company will postpone its decision about the initiation of a Phase 2/3 clinical trial of PTG-100 in chronic
pouchitis until after its full review of the interim data from the UC PROPEL study.
Arshad Cheema said that one patient developed
pouchitis, two had intra-abdominal collection, one had pouch bladder fistula.
Of the 86 patients, 11 had Clavien-Dindo I complications (6 with ileus and 5 with wound infection not requiring intravenous antibiotics), 22 had Clavien-Dindo II complications (14 with wound infection requiring intravenous antibiotics, 5 with
pouchitis, and 3 with intra-abdominal infection), and 2 had Clavien-Dindo III complications (1 with intra-abdominal infection requiring stoma reconstruction under general anesthesia and with 1 intra-abdominal infection requiring reoperation on POD 10).
showed that fecal MMP-9 has high sensitivity in the detection of endoscopically active UC and
pouchitis, indicating that the noninvasive method of MMP-9 determination can help assess intestinal inflammation.
Previous studies have demonstrated Bifico to improve colitis and colitis-associated malignancy,
pouchitis, diarrhea, and gastritis in models.
Additionally, no adverse effects arose after 10 months of vedolizumab and etanercept dual therapy in treating chronic
pouchitis and spondyloarthritis [5].
In the subsequent 15 years, he was treated for three episodes of
pouchitis where each responded well to three weeks of ciprofloxacin and metronidazole
