There is a high demand from the pharmaceutical industry for CMOs to manufacture potent
molecules for use in drugs that improve efficacy and reduce side effects.
The higher level of receptors is what makes morphine more potent
in males because less drug is required to activate enough receptors to reduce the experience of pain.
Third generation inhibitors osimertinib, EGF816, and rociletinib were all significantly less potent
for exon 20 mutations/insertions compared with T790M.
In these studies, OK-113 was as potent
as cyclosporine, an immunosuppressive drug which is the active ingredient of Restasis (Allergan).
It turned out that the supplements that the man was carrying contain sibutramine, a potent
substance that is banned in Russia.
Tests by HSA found that the product contained betamethasone valerate (a potent
steroid) and clotrimazole (an antifungal medicine).
LEXETTE is a new formulation of halobetasol, a potent
topical corticosteroid, which is indicated for the treatment of plaque psoriasis in adult patients, added the company.
"Across our sites, Cambrex has a strong reputation in the handling and supply of potent
molecules, and this investment allows us to increase the capacity we can offer our customers," said John Andrews, vice president, operations and site director, Cambrex Charles City.
LEXETTE will be supported by our existing psoriasis-focused sales team who will now be able to offer a potent
steroid along with steroid-free SORILUX Foam, which are both commonly used in psoriasis treatment protocols.
Currently treating the severe stomach bug can be difficult as antibiotics are known to make the disease worse by releasing a potent
toxin into the infected person's gut, scientists said.
Recipharm AB (STO:RECIB), a leading Contract Development and Manufacturing Organisation (CDMO) in the pharmaceutical industry, announced on Thursday that following a routine audit, the UK Medicines and Healthcare Products Regulatory Agency (MHRA) has restricted the manufacturing licence for five non-critical highly potent
products supplied from the Recipharm facility located in Ashton-u -Lyne, UK.
POLICE have issued an urgent warning about a particularly potent
batch of a synthetic drug thought to be circulating in Neath and Port Talbot Officers say in recent days a heroin user in the area tested positive for fentanyl following a non-fatal overdose.