potency ratio

potency ratio

Pharmacology The ratio of the effect of a member of a particular family of drugs–eg, corticosteroids or analgesics, to that of
a benchmark agent
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Potency ratio for 8-THC was estimated to be between 1:2 and 2:3 (8-THC: 9-THC) (Hollister and Gillespie, 1973; Karniol and Carlini, 1973).
Therefore, the potency ratio found in these studies, (33,34) is only valid for the median effective analgesic concentrations (EC50) which does not permit conclusions about the potency ratio for the ED95.
[5] Potency ratio of sufentanil/fentanyl has been reported to be 5-7:1 for intravenous administration, but we cannot extrapolate this data in case of epidural route.
Table 5: Mean Performance of Parental Lines, Hybrids and Estimation of Percent Heterosis, Heterobeltiosis and Potency Ratio for Flag Leaf Area in Wheat
For example, Hodgson and Darnton (2000) found a potency ratio of 1:100:500 for chrysotile, amosite, and crocidolite, respectively, and Berman and Crump (2008a) reported estimates in the same range.
Whether the addition of fentanyl to local anaesthetic changes the potency ratio or the characteristics of blockade has not been examined, and most studies have involved orthopaedic surgery, with few involving lower abdominal surgery.
"A potency ratio of 1:3 was safe and provided good pain control over a wide morphine dose, and that's our recommendation," he said.
The study was designed to determine the minimum effective doses ([ED.sub.50]) of the two vasopressors and thus to estimate a potency ratio, using Dixon's up-down method of sequential allocation of doses.
where subscripts A and J refer to the adult and juvenile period, respectively; [lambda] is the natural logarithm of the juvenile:adult cancer potency ratio; [P.sub.0] is the fraction of control animals with the particular tumor type being modeled; [P.sub.x] is the fraction of animals exposed in age period x with the tumor; [m.sub.A] is the cancer potency, the rate of accumulation of "hits" per unit of time for adults; and [[delta].sub.x] is the duration or number of exposures during age period x.
Another trial with a lower starting dose and smaller dose interval of mephentermine is required to determine the potency ratio of mephentermine and ephedrine