Co-prescription of potassium-sparing diuretics
may be more effective than the use of potassium supplements.
Indomethacin, potassium-sparing diuretics
, and/or aldosterone receptor antagonists have been also recommended .
I believe these results will return potassium-sparing diuretics
to prominence," said Dr.
Thiazides are the first-line choice of diuretic (loop and potassium-sparing diuretics
are more likely to be used if you have heart failure), but they may not be suitable for people with impaired kidney function.
Three subclasses of diuretics can be used to treat HTN: loop diuretics, potassium-sparing diuretics
, and thiazide diuretics.
The study authors suggested that the beneficial effect on urinary excretion could be similar to action of potassium-sparing diuretics
due to unchanged potassium levels in the Se-SM group.
Decrease potassium replacement if serum potassium is raised or decrease/stop potassium-sparing diuretics
The classes of drugs used to treat hypertension are angiotensin-converting-enzyme inhibitors (ACEIs), angiotensin 1I receptor antagonists (ARBs), direct renin antagonists, calcium channel blockers (CCBs), alpha-1 blockers, direct vasodilators, diuretics, beta-blockers (BBs), potassium-sparing diuretics
, aldosterone receptor blockers and centrally acting alpha-2 antagonists.
Spironolactone HCl is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist in the class of pharmaceuticals known as potassium-sparing diuretics
. It is indicated in the management of primary hyperaldosteronism, edematous conditions (for patients with congestive heart failure, cirrhosis of the liver accompanied by edema and/or ascites, the nephritic syndrome), essential hypertension, hypokalemia and severe heart failure (NYHA class III-IV).
Also at risk is anyone on a medication that causes the body to hold onto potassium, including potassium-sparing diuretics
like Dyazide and Spirozide, ACE inhibitors like Lotensin and Vasotec, angiotensin-receptor blockers such as Tevetan and Avapro and daily doses of nonsteroidal anti-inflammatory drugs like aspirin and ibuprofen.
Types of diuretics include thiazides, such as Diuril (chlorothiazide) and Esidrex (hydrochlorothiazide); potassium-sparing diuretics
, such as Aldactone (spironolactone); and loop diuretics, such as Lasix (furosemide).
A large study, reported in the May 2006 Archives of Neurology, found that use of potassium-sparing diuretics
to control hypertension resulted in lowering Alzheimer's risk by more than 70 percent.