potassium-sparing diuretic


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potassium-sparing diuretic

Medtalk A diuretic that effects mild diuresis, while conserving K+ and Mg2+; PSDs may be more effective in maintaining the electrolyte balance than cation–K+, magnesium supplementation; PSDs include amiloride, triameterene, diazide, maxide, spironolactone See Diuretics. Cf Loop diuretic.

potassium-sparing diuretic

An agent that stimulates the kidneys to excrete water and sodium while retaining potassium. Drugs from this therapeutic class are used to treat hypertension, fluid retention in cirrhosis, and congestive heart failure.
See also: diuretic
References in periodicals archive ?
POTASSIUM-SPARING DIURETICS All potassium-sparing diuretics have a weak antihypertensive effect when used by themselves.
Hyperkalaemia--a plasma potassium level of 5.5mmol/L or higher--can develop with the use of potassium-sparing diuretics. Again, symptoms are nonspecific and include lethargy, weakness, a flaccid paralysis and palpitations.
Hyperkalemia is also a possible side effect, especially for patients diagnosed with diabetes or renal impairment, or taking ACE inhibitors in combination with potassium-sparing diuretics (Adams et al., 2014).
The classes of drugs used to treat hypertension are angiotensin-converting-enzyme inhibitors (ACEIs), angiotensin 1I receptor antagonists (ARBs), direct renin antagonists, calcium channel blockers (CCBs), alpha-1 blockers, direct vasodilators, diuretics, beta-blockers (BBs), potassium-sparing diuretics, aldosterone receptor blockers and centrally acting alpha-2 antagonists.
Also at risk is anyone on a medication that causes the body to hold onto potassium, including potassium-sparing diuretics like Dyazide and Spirozide, ACE inhibitors like Lotensin and Vasotec, angiotensin-receptor blockers such as Tevetan and Avapro and daily doses of nonsteroidal anti-inflammatory drugs like aspirin and ibuprofen.
Types of diuretics include thiazides, such as Diuril (chlorothiazide) and Esidrex (hydrochlorothiazide); potassium-sparing diuretics, such as Aldactone (spironolactone); and loop diuretics, such as Lasix (furosemide).
A large study, reported in the May 2006 Archives of Neurology, found that use of potassium-sparing diuretics to control hypertension resulted in lowering Alzheimer's risk by more than 70 percent.
Elderly patients who took potassium-sparing diuretics had a 70% lower rate of developing Alzheimer's disease than those who did not take antihypertensive drugs in a population-based study of dementing illnesses, reported Ara S.
It should be used with caution in women on other medications that can increase potassium, including NSAIDs, potassium-sparing diuretics, ACE inhibitors, or angiotensin II receptor antagonists.
Potassium-sparing diuretics obviously may spare potassium and magnesium.
Persons taking frusemide and the potassium-sparing diuretics had higher creatinine levels than those taking thiazides.