To overcome clinical diagnostic challenges, more emphasis is being given using other -omics approaches to analyze the functional consequences of genomic data at the levels of RNA, protein, epigenomics,
posttranslational modifications, metabolites, and RNA-seq in particular (2), as recommended by American College of Medical Genetics and Genomics guidelines.
In the mouse hippocampus, long-term memory (LTM) formation is tightly coupled to de novo gene expression of plasticity-related proteins and
posttranslational modifications [43-45] and relies on intact cAMP/protein kinase A (PKA)/protein kinase C (PKC)/CREB/ERK signaling [43, 46,47] including chromatin remodeling [48-54].
Several mutations may occur in the TSHR gene that influence either the protein component or
posttranslational modifications of the receptor.
Gatto Jr., "Protein
posttranslational modifications: the chemistry of proteome diversifications," Angewandte Chemie International Edition, vol.
CIITA is 1130 amino acid protein and is dynamically regulated through an intricate series of
posttranslational modifications (PTMs) [10].
Numerous regulatory
posttranslational modifications (PTM), such as phosphorylation, acetylation, ubiquitination, and sumoylation, have been reported and shown to have effects on activating or inhibiting NF-[kappa]B induced by diverse agents.
She also describes the inherent difficulties when applying current high throughput technologies to this task due to the biochemical nature of membrane proteins, causing problems with solubility, correct folding, and
posttranslational modifications. Also, the fast dissociation rates and low affinity for some of these interactions require further modifications not present in the natural proteins.
Histone
posttranslational modifications (PTMs) regulate gene expression chromatin structure.
While there are several different types of epigenetic mechanisms, protein
posttranslational modifications (PTM) are intriguing contributors in regulating aging [22-27].
Recently, emerging evidences demonstrated that hypertrophied heart is accompanied by proliferating of cardiac microtubules and altered the
posttranslational modifications (PTMs) on tubulin, such as detyrosination and acetylation of tubulin [3].