An intracellular signal transduction cascade, culminating in the activation of Hog1, a yeast homolog of MAPK, conveys stress signal downstream, initiating both posttranslational
and transcriptional regulatory events (Mettetal et al.
Differential requirement of CAAX-mediated posttranslational
processing for Rheb localization and signaling.
2011), alterations in posttranslational
histone modifications (Kim and Shukla 2005; Pal-Bhadra et al.
In fact, biologics are rarely, if ever, limited to a single defined entity; typically, biologics contain a range of discrete molecular entities, differing in posttranslational
modifications or other minor structural features.
of Chemistry & Chemical Biology, Harvard University "Thiazole Peptide Antibiotic Biosynthesis: A Cascade of Posttranslational
Modification of Transcription Factors and Inflammatory Signaling Molecules
modification, protein turnover, and chaperones (10.
A speculation on the source of these antibodies suggests that posttranslational
modifications (glycosylation and phosphorylation) of some proteins may create neo-epitopes for the production of autoantibodies (14, 15).
PADI4 gene encodes an enzyme that is responsible for posttranslational
conversion of arginine residues to citrulline.
Of these identified proteins, enzyme digestions and chemical oxidation suggest posttranslational
modifications of some proteins e.
GGTase I catalyzes the lipid posttranslational
modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer).
REGULATION OF THE TUMOR-SUPPRESSOR IKAROS BY