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Referring to events that occur after translation.
Farlex Partner Medical Dictionary © Farlex 2012


(pōst′trăns-lā′shə-nəl, -trănz-)
Of or relating to a substance or process, such as the addition of sugar groups to form a glycoprotein, that occurs or is formed after translation of protein: a posttranslational modification.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
Recent studies have suggested that the structural differences among TZDs might not only result in increased PPAR[gamma] expression, but also result in ligand-dependent posttranslational modifications of PPAR[gamma] [15, 22].
In the near future, a combination of time-resolved immunoprecipitation or similar techniques [98, 99] in combination with mass spectrometric analysis of the different complexes, their components, and the posttranslational status of its protein components will shed new light on the complex yet delicate regulation of PER1 within a cell traveling through circadian time.
Parallel with rat PMC EMT, ALK-5 (TGF-[sz]RI) and TGF-[sz]RII protein expression were increased following their posttranslational CF upregulation [Figure 4].
Anderson et al., "Lysine glutarylation is a protein posttranslational modification regulated by SIRT5," Cell Metabolism, vol.
While MHC II is regulated at the level of transcription, CIITA is tightly regulated at the level of posttranslational modification.
Activation of cell survival-associated ERK1/2 pathway is regulated by mechanisms related to posttranslational modifications, including downstream scaffolds and phosphorylation of threonine and tyrosine residues.
The present research was designed to document the beneficial effects of GGD on pressure overload-induced heart failure on mice and to investigate the role of GGD on the expression and posttranslational modifications of [alpha]-tubulin.
A vast range of posttranslational modifications cover functions of modified proteins leading to complexity of life.
We identified similar regulatory effects at the transcriptional and posttranslational levels by pharmacological interference after treating cells with piceatannol, a Syk inhibitor (Figures 1(b) and 3(d)).
Several epigenetic mechanisms, including posttranslational histone modifications, DNA methylation, and microRNAs (miRNAs), determine the specific chromatin structure, consequently influencing gene transcription without altering the DNA sequence itself [61].
found that daily topical application of 5% L-ascorbic acid enhanced the levels of procollagen types I and III, their posttranslational maturation enzymes, and tissue inhibitor of matrix metalloproteinase.
By inhibiting HMG-CoA reductase, statins lower production of farnesyl pyrophosphate and geranylgeranyl pyrophosphate, which are needed for posttranslational activation of Ras, Rho, and other proteins that are overexpressed in CRC and that have been linked to tumor invasion.

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