Recent studies have suggested that the structural differences among TZDs might not only result in increased PPAR[gamma] expression, but also result in ligand-dependent posttranslational
modifications of PPAR[gamma] [15, 22].
In the near future, a combination of time-resolved immunoprecipitation or similar techniques [98, 99] in combination with mass spectrometric analysis of the different complexes, their components, and the posttranslational
status of its protein components will shed new light on the complex yet delicate regulation of PER1 within a cell traveling through circadian time.
Parallel with rat PMC EMT, ALK-5 (TGF-[sz]RI) and TGF-[sz]RII protein expression were increased following their posttranslational
CF upregulation [Figure 4].
Anderson et al., "Lysine glutarylation is a protein posttranslational
modification regulated by SIRT5," Cell Metabolism, vol.
While MHC II is regulated at the level of transcription, CIITA is tightly regulated at the level of posttranslational
Activation of cell survival-associated ERK1/2 pathway is regulated by mechanisms related to posttranslational
modifications, including downstream scaffolds and phosphorylation of threonine and tyrosine residues.
The present research was designed to document the beneficial effects of GGD on pressure overload-induced heart failure on mice and to investigate the role of GGD on the expression and posttranslational
modifications of [alpha]-tubulin.
A vast range of posttranslational
modifications cover functions of modified proteins leading to complexity of life.
We identified similar regulatory effects at the transcriptional and posttranslational
levels by pharmacological interference after treating cells with piceatannol, a Syk inhibitor (Figures 1(b) and 3(d)).
Several epigenetic mechanisms, including posttranslational
histone modifications, DNA methylation, and microRNAs (miRNAs), determine the specific chromatin structure, consequently influencing gene transcription without altering the DNA sequence itself .
found that daily topical application of 5% L-ascorbic acid enhanced the levels of procollagen types I and III, their posttranslational
maturation enzymes, and tissue inhibitor of matrix metalloproteinase.
By inhibiting HMG-CoA reductase, statins lower production of farnesyl pyrophosphate and geranylgeranyl pyrophosphate, which are needed for posttranslational
activation of Ras, Rho, and other proteins that are overexpressed in CRC and that have been linked to tumor invasion.