As miRNAs are sequenced directly, information about sequence variations or posttranscriptional
RNA editing becomes available for further analysis.
We now understand that regulation of cell functions is significantly more complex, and includes posttranscriptional
The vector comprises a protein shell derived from adeno-associated virus serotype 1 (AAV1), the promoter, a posttranscriptional
regulatory element and AAV2 derived inverted terminal repeats.
His research interests include molecular epidemiology, molecular biology and mechanism of pathogenesis of rotavirus and EVs, and posttranscriptional
regulation of gene expression.
The mechanism of tocotrienol's hypolipidemic action involves posttranscriptional
suppression of HMGR (3-hydroxy-3-methyl-glutaryl-CoA reductase--the enzyme/protein responsible for the body's cholesterol production) via controlled degradation of the reductase protein.
mechanisms participate in induction of C-reactive protein and serum amyloid A by IL-6 and IL-I?
Transcriptional and posttranscriptional
regulation by expansion of the "free" iron pool.
regulation of miRNAs harboring conserved terminal loops.
With coverage of genes and chromosomes, DNA replication and recombination, transcription and posttranscriptional
mechanisms, and gene regulation, this text can be used in advanced undergraduate or graduate courses in molecular genetics and molecular biology.
2003) Acidosis downregulates leptin production from cultured adipocytes through a glucose transport-dependent posttranscriptional
Some epigenetic mechanisms take place in the nucleus (DNA methylation, posttranscriptional
modifications of histones, chromatin remodeling), whereas others occur in the cytoplasm (mRNA processing).
Although a few examples are known of posttranscriptional
regulation, GST gene expression is regulated predominantly at the transcriptional level (Marrs, 1996; Davies & Caseley, 1999).