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For example, electron microscopic studies have demonstrated a positive correlation between the volume of a spine and postsynaptic density (PSD).n) The PSD is a large protein complex that anchors a diverse variety of neurotransmitter receptors, channels, adhesion molecules, and scaffold proteins.
The authors attributed the 48 h rise in GluN1 mainly to an increase in NMDARs at the cell surface, though not at the synaptic membrane, as GluN1 was not significantly higher in the postsynaptic density fraction [30].
PSD95 (Postsynaptic density protein 95) is the most important scaffold protein on the postsynaptic membrane, which plays an important role in the process of synapse formation.
Tymianski, "Postsynaptic mechanisms of excitotoxicity: involvement of postsynaptic density proteins, radicals, and oxidant molecules," Neuroscience, vol.
Voltage-gated calcium channels (VGCCs) were added uniformly to the spine, whereas the NMDARs were concentrated at the postsynaptic density (PSD).
Glutamate then activates NMDA receptors [~50 NMDA receptors dispersed over a 400-nm-diameter postsynaptic density (1) at postsynaptic membrane which further propagates excitatory impulse to cell body and also it activates calcium and calmodulin to bind with each other (2) and causes release of nitric oxide (NO) from nitric oxide synthetase (NOS) (One NOS molecule generates 20 NO molecules per second).
Compared to glial cells, insulin receptors are present more in neurons [2] and are concentrated at the postsynaptic density [3].
Kennedy, "Signal-processing machines at the postsynaptic density," Science, vol.
So to look into these issues with more details, the current experimental study employed transmission electron microscopy to compare the effects of morphine consumption on synaptic plasticity, postsynaptic density thickness, and synaptic curvatures in CA1 area of hippocampus formations.
Within each synapse is a set of proteins, which, like the components of an engine, bind together to build a molecular machine called the postsynaptic density -- also known as the PSD.
KEY WORDS: [alpha]CaMKII, brain growth spurt, developmental neurotoxicity, field-EPSP recording, hippocampal synaptic plasticity, postsynaptic density. Environ Health Perspect 115:865-870 (2007).
The postsynaptic terminals were seen to contain subsynaptic cisterns formed by membranes of smooth endoplasmic reticulum beneath the postsynaptic density, whereas the presynaptic terminal showed numerous electron transparent synaptic vesicles.