Synapses can be excitatory or inhibitory, depending on whether they activate or inhibit the postsynaptic
CBI-3 also produces rapid excitatory postsynaptic
potentials (EPSPs) in B40, resulting in feedforward inhibition of egestive motor patterns.
Additionally atropine and scopolamine had showed 10 times higher affinity for presynaptic receptors than postsynaptic
The impairment of the homeostatic mitochondrial transport system to both pre and postsynaptic
terminals has been shown to cause synaptic loss, as the mitochondria are essential for Ca+ homeostasis .
One possible explanation for these observations is that astrocytes can operate at slower timescales than neurons [23, 24] and thus could possibly maintain activity in postsynaptic
neurons after stimulation of the presynaptic neurons has stopped.
The mechanism for the expression of LTP mainly depends on changes in the number and/or properties of AMPA receptors in the postsynaptic
It is physiologically controlled by excitatory presynaptic potentials of Ia afferent fibers and inhibitory postsynaptic
potentials from muscle spindles of antagonistic muscles.
Congenital myasthenic syndromes (CMSs [MIM 608931]) represents a group of clinically and genetically heterogeneous disorders caused by impaired neuromuscular junction (NMJ) transmission leading to fatigable weakness.[sup] Conventionally, CMS were classified on the basis of the location of a mutated protein as presynaptic, synaptic basal lamina-associated, or postsynaptic
. Currently, gene defects that influence the development and maintenance of NMJ are assigned to a separate group of the CMS and rank second in the disease causes following defects of the acetylcholine receptors (AChRs).[sup] These genes include RAPSN , DOK7 , LRP4 , MUSK , and AGRN .[sup], Agrin, encoded by AGRN , is a cell-specific heparan sulfate proteoglycan generated by alternative splicing.
It is characterized by decrease in the number of available nicotinic acetylcholine receptors at postsynaptic
membrane due to presence of pathogenic autoantibodies [1, 2].
CA3-CA3 and mossy fiber-CA3 synapses were studied; spontaneous and evoked postsynaptic
current were recorded in placebo and treated mice.
According to the mechanism of action, neurotoxins can be classified as presynaptic type and postsynaptic
We chose the neurons of the primary somatosensory cortex as the target area to investigate the effects of ketamine on the glutamate receptors-related spontaneous excitatory postsynaptic
currents (sEPSCs) and miniature excitatory postsynaptic
currents (mEPSCs) in rats.