growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.
The lysosome-autophagy system is the main catabolic pathway for recycling of protein aggregates and damaged organelles, and its role as a quality control system is especially critical in neurons, due to their postmitotic
and highly specialized nature.
A well-established model of postmitotic
human dopaminergic neurons (LUHMES cells) was used in the absence of or in co-culture with astrocytes to investigate the mechanisms involved in the endogenous neurodefensive activity of astrocytes.
The loss of ASPM leads to a premature switch from symmetric to asymmetric cell division, decreasing the number of postmitotic
neurons in the developing cortex, reflected in a reduced cortical surface area and a simplified gyral pattern.
In the genetargeting mutation mice model, XRCC4 gene inactivation results in late embryonic mortality along with defective lymphogenesis and defective neurogenesis characterized by broad apoptotic death of newly produced postmitotic
Mitotically active ganglia in the setting of colonic inertia would support the notion that neurons, classically believed to be postmitotic
, can divide during appropriate conditions, (22) or that cells with progenitor potential that give rise to neurons and glial cells persist in the adult colon.
Due to their postmitotic
phenotype, odontoblasts are difficult to culture [3, 4]; thus, biochemical or toxicologic studies assessing their use in dental materials have been limited.
CMs were previously thought to be postmitotic
, but recent studies have shown that cardiac tissue possesses some intrinsic mitotic activity with some regenerative potential as it contains a diversity of stem cells with regenerative potential in various niches in the heart .
When the cultures were treated with CORM-A1, the final number of postmitotic
neurons was duplicated.
NeuN is an antigen used widely in research and diagnostics to identify postmitotic
The use of dual AAV2/8 systems for the delivery of CRISPR-Cas9 components into the retina was also used to knock out the Nrl (neural retina-specific leucine zipper) gene in postmitotic
As a result, they are primarily used for the transduction of postmitotic