Specifically, We intend to screen for genetic elements affecting htt repeat length instability in dividing and postmitotic
Satb2 is a postmitotic
determinant for upper-layer neuron specification in the neocortex.
Rb and p130 control cell cycle gene silencing to maintain the postmitotic
phenotype in cardiac myocytes.
In the vertebrate brain, postmitotic
neurons are generated from neuroepithelial cells and they start to extend long axonal processes and relatively short, branched dendrites after their migration to appropriate brain regions.
The lysosomal-mitochondrial axis theory of postmitotic
aging and cell death.
sup] However, little attention has been paid to the CS of postmitotic
neurons in the aged central nervous system (CNS), which may be related with the severity of cognitive impairments.
Interestingly, the production of intracellular A[beta] from wild-type APP695 appears to be a unique characteristic of postmitotic
neurons, since intracellular A[beta] was not detected in several nonneuronal cell lines .
Several studies evidenced data suggesting that EMX2 gene may be involved in the modulation of cell proliferation of cortical neuroblasts and/or cell migration of postmitotic
neurons, as it is known that these cells reach their final destination in the mature cortex according to their generation date.
These cortical developmental anomalies can be grouped into three categories: 1) abnormal proliferation of neurons and glia; 2) abnormal migration of postmitotic
neurons to the cortical plate; and 3) abnormal cortical organization and elaboration of connections.
Cell cycle activation in postmitotic
neurons is essential for DNA repair.
Pre-study has reported caspase-3 is expressed in postmitotic
dopaminergic neurons and caspase-3 activation could result in dopaminergic neuronal apoptosis in PD model, which may represent a common integration point and constitute an attractive target for antiapoptotic therapy in PD (Hartmann et al.
Pre- and postmitotic
reorientation of microtubule arrays in young Sphagnum leaflets: transitional stages and initiation sites.