Sleep Symptoms During the Menopausal Transition and Early Postmenopause
: Observations from the Seattle Midlife Women's Health Study.
Heart disease is the biggest killer of women, with the risk of developing coronary disease increasing more rapidly postmenopause
and developing coronary disease five to 10 years later than men on average.
* If we are expecting a rapid rate of change in bone density, such as in the early postmenopause
or in the first few years after starting treatment for osteoporosis, we check bone density every year.
Estradiol is the main hormone produced by the ovary that is decreased significantly in postmenopause
; estriol is a degraded product of estradiol; and estrone is a hormone that remains almost at the same premenopausal level due to extragenital production from the androgen (11-14).
As life expectancy is increasing in terms of age in women and menopause remains relatively unchanged, so women are now spending more of their life in the postmenopause
Specifically, hormone therapy has proven to be the most effective treatment for VMS, whereas sex hormone levels also are related to postmenopause
breast cancer risk.
Secondary analysis of ELITE trial data among 596 women in early (<6 years) and late (>10 years) postmenopause
indicates that estradiol (E2) plasma levels resulting from oral E2 administration were inversely associated with atherosclerosis progression in the women in early menopause, but positively associated with atherosclerosis progression in those in late menopause
The mean age of patients was highest in the late postmenopause
group (60.72[+ or -]6.51), and this was significant compared to the other groups.
In this analysis, 22 of the earliest postmenopause
women received prasterone, seeing a 1.59-point drop in dyspareunia severity.
Similarly, the pre- to postmenopause
change in median FSH from 38.6 to 62.8 IU/L in the stable migraine group didn't attain statistical significance, while the bigger shift in the migraine change group--from 13.5 IU/L premenopausally to 62.2 IU/L post menopause, was statistically significant.
, the bone degradation is accelerated by about 20% compared
The researchers found that poor sleep in premenopause did not predict poor sleep in perimenopause, and similarly, poor sleep in perimenopause did not predict poor sleep in postmenopause
. There was a high correlation between the frequencies of each of the measures of poor sleep.